), 刘苏姣, 张冉冉, 徐鹏 贵州医科大学医学人文学院, 贵阳 550025
收稿日期:2020-12-29发布日期:2021-06-25通讯作者:严万森E-mail:yanwansen@163.com基金资助:国家自然科学基金(32060195)The susceptibility of compulsive traits and neural substrates of the prefrontal and anti-reward systems implicated in drug addiction
YAN Wan-Sen(), LIU Su-Jiao, ZHANG Ran-Ran, XU Peng College of Medical Humanities, Guizhou Medical University, Guiyang 550025, China
Received:2020-12-29Published:2021-06-25Contact:YAN Wan-Sen E-mail:yanwansen@163.com摘要/Abstract
摘要： 强迫性是一种与不顾严重后果的固着行为密切相关的神经心理结构, 大脑神经系统对强迫性行为的调控机制崩溃是导致药物成瘾的直接原因。以往研究对于奖赏系统(中脑-皮层-边缘神经环路)在成瘾行为中的作用及机制已经具有丰富的了解, 但针对药物成瘾的强迫性特征本身以及前额叶-反奖赏系统神经环路在成瘾行为中的作用机制了解有限, 尤其是缺乏对药物成瘾强迫性特征的系统考察、缺少遗传学研究以及非兴奋剂类药物的汇聚证据。项目拟结合人类成瘾行为的遗传学视角(海洛因成瘾者与其无药物使用的兄弟姐妹对照), 结合神经认知、脑电生理、神经影像等不同层面的方法和技术, 对药物成瘾强迫性的外在表征、神经生物学基础以及与个体差异有关的遗传易感性进行探索, 期在进一步识别药物成瘾的神经生物标记, 为探寻潜在的药物或非药物干预靶点提供更多证据。
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