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Translational Informatics for Parkinson’s Disease: from Big Biomedical Data to Small Actionable Alte
Parkinson'sdisease(PD)isacommonneurologicaldiseaseinelderlypeople,anditsmorbidityandmortalityareincreasingwiththeadventofglobalageing.Thetraditionalpa ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs
Blood-bornesmallnon-coding(sncRNAs)areamongtheprominentcandidatesforblood-baseddiagnostictests.Often,high-throughputapproachesareappliedtodiscoverbiom ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectiv
Majorityoftype2diabetesmellitus(T2DM)patientsarehighlysusceptibletoseveralformsofcognitiveimpairments,particularlydementia.However,theunderlyingneural ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders
Denovovariants(DNVs)areoneofthemostsignificantcontributorstosevereearly-onsetgeneticdisorderssuchasautismspectrumdisorder,intellectualdisability,andot ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis
Gliomasareoneofthemostcommontypesofbraincancers.Numerouseffortshavebeendevotedtostudyingthemechanismsofgliomagenesisandidentifyingbiomarkersfordiagnos ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Mapping Genome Variants Sheds Light on Genetic and Phenotypic Differentiation in Chinese
遗传变异和人类健康和精准医疗息息相关，因此绘制全人类基因组遗传变异图谱成为全球科学家共同奋斗的目标。近年来，国际千人基因组等多个研究小组纷纷致力于发现世界不同种族人群中基因组变异。我国是个多民族国家，拥有大约20%的世界人口和丰富的遗传多样性。但由于缺乏中国南北方人群特异的参考基因组以及深度测序数据 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome
Tounravelthegeneticmechanismsofdiseaseandphysiologicaltraits,itrequirescomprehensivesequencinganalysisoflargesamplesizeinChinesepopulations.Here,werep ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus
Systemiclupuserythematosus(SLE)isacomplexautoimmunesyndromecharacterizedbyvariousco-existingautoantibodies(autoAbs)inpatients’blood.However,thefullspe ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Proteomics Analysis of Lipid Droplets from the Oleaginous Alga Chromochloris zofingiensis Reveals No
Chromochloriszofingiensisrepresentsanindustriallyrelevantanduniquegreenalga,givenitscapabilityofsynthesizingtriacylglycerol(TAG)andastaxanthinsimultan ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name
Ithasbeenobservedthatbothcancertissuecellsandnormalproliferatingcells(NPCs)havetheWarburgeffect.Ourgoalhereistodemonstratethattheydothisfordifferentre ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from
TcellsandTcellreceptors(TCRs)playpivotalrolesinadaptiveimmuneresponsesagainsttumors.Thedevelopmentofnext-generationsequencingtechnologieshasenabledthe ...
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H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors
Drosophilaneuraldevelopmentundergoesextensivechromatinremodelingandpreciseepigeneticregulation.However,therolesofchromatinremodelinginestablishmentand ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
gFACs: Gene Filtering, Analysis, and Conversion to Unify Genome Annotations Across Alignment and Gen
Publishedgenomesfrequentlycontainerroneousgenemodelsthatrepresentissuesassociatedwithidentificationofopenreadingframes,startsites,splicesites,andrelat ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
C3: Consensus Cancer Driver Gene Caller
Next-generationsequencinghasallowedidentificationofmillionsofsomaticmutationsinhumancancercells.Akeychallengeininterpretingcancergenomesistodistinguis ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interact
Proteinsusuallyassociatewithothermoleculesphysicallytoexecutetheirfunctions.Identifyingtheseinteractionsisimportantforthefunctionalanalysisofproteins. ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differ
Theactivationmechanismofchimericantigenreceptor(CAR)-engineeredTcellsmaydiffersubstantiallyfromTcellscarryingnativeTcellreceptor,butthisdifferencerema ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Global Quantitative Mapping of Enhancers in Rice by STARR-seq
Enhancersactivatetranscriptioninadistance-,orientation-,andposition-independentmanner,whichmakesthemdifficulttobeidentified.Self-transcribingactivereg ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
N6-methyladenosine(m6A),catalyzedbythemethyltransferasecomplexconsistingofMettl3andMettl14,isthemostabundantRNAmodificationinmRNAsandparticipatesindiv ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,08
Emergingantibioticresistanceisamajorglobalhealththreat.Theanalysisofnucleicacidsequenceslinkedtosusceptibilityphenotypesfacilitatesthestudyofgenetican ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent
Majordepressivedisorder(MDD)isthemostcommonnonfataldiseaseburdenworldwide.Systemicchroniclow-gradeinflammationhasbeenreportedtobeassociatedwithMDDprog ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL
Chimericantigenreceptor(CAR)Tcelltherapyhasexhibiteddramaticanti-tumorefficacyinclinicaltrials.Inthisstudy,wereportedthetranscriptomeprofilesofbonemar ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SSCC: A Novel Computational Framework for Rapid and Accurate Clustering Large-scale Single Cell RNA-
ClusteringisaprevalentanalyticalmeanstoanalyzesinglecellRNAsequencing(scRNA-seq)databuttherapidlyexpandingdatavolumecanmakethisprocesscomputationallyc ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-generation Sequencing Data
Asnext-generationsequencing(NGS)technologyhasbecomewidelyusedtoidentifygeneticcausalvariantsforvariousdiseasesandtraits,anumberofpackagesforcheckingNG ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Deep Learning Deepens the Analysis of Alternative Splicing
基因组学数据在数据量和数据维度上的日益增长，给传统的数据分析方法带来了挑战，同时也为开发新的分析方法提供了机会。近年来，深度学习推动了人工智能和机器学习领域新一波的浪潮。最近，美国加利福尼亚大学洛杉矶分校的邢毅教授（现为费城儿童医院教授）实验室开发了一个全新的计算框架：DARTS[1]。DARTS通 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Stereotypes About Enterotype: the Old and New Ideas
In2011,theterm“enterotype”firstappearedtothegeneralpublicinNature,whichreferstostratificationofhumangutmicrobiota.However,withmorestudiesonenterotypes ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Intestinal Microbiota in Early Life and Its Implications on Childhood Health
Trillionsofmicrobesresideinthehumanbodyandparticipateinmultiplephysiologicalandpathophysiologicalprocessesthataffecthosthealththroughoutthelifecycle.T ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Ass
Variationofmaternalgutmicrobiotamayincreasetheriskofautismspectrumdisorders(ASDs)inoffspring.Animalstudieshaveindicatedthatmaternalgutmicrobiotaisrela ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Antibiotic Treatment Drives the Diversification of the Human Gut Resistome
Despitethedocumentedantibiotic-induceddisruptionofthegutmicrobiota,theimpactofantibioticintakeonstrain-leveldynamics,evolutionofresistancegenes,andfac ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Effects of Proton Pump Inhibitors on the Gastrointestinal Microbiota in Gastroesophageal Reflux Dise
Protonpumpinhibitors(PPIs)arecommonlyusedtolessensymptomsinpatientswithgastroesophagealrefluxdisease(GERD).However,theeffectsofPPItherapyonthegastroin ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptin-related Pathwa
Inulinhasbeenusedasaprebiotictoalleviateglucoseandlipidmetabolismdisordersinmiceandhumansbymodulatingthegutmicrobiota.However,themechanismunderlyingth ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Agricultural Risk Factors Influence Microbial Ecology in Honghu Lake
Agriculturalactivities,includingstock-farming,plantingindustry,andfishaquaculture,canaffectthephysicochemicalandbiologicalcharactersoffreshwaterlakes. ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
How Microbes Shape Their Communities? A Microbial Community Model Based on Functional Genes
Exploringthemechanismsofmaintainingmicrobialcommunitystructureisimportanttounderstandbiofilmdevelopmentormicrobiotadysbiosis.Inthispaper,weproposeafun ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
GPA: A Microbial Genetic Polymorphisms Assignments Tool in Metagenomic Analysis by Bayesian Estimati
Identifyingantimicrobialresistant(AMR)bacteriainmetagenomicssamplesisessentialforpublichealthandfoodsafety.Next-generationsequencing(NGS)technologyhas ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
From Basic Research to Molecular Breeding — Chinese Scientists Play A Central Role in Boosting World
OnNovember18,2018,theFutureSciencePrizeAwardingCeremonywasheldinBeijing.Intheareaoflifescience,ProfessorsJiayangLi,LongpingYuan,andQifaZhangsharedthep ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Development of the “Third-Generation” Hybrid Rice in China
RiceisamajorcerealcropforChina.Thedevelopmentofthe“three-line”hybridricesystembasedoncytoplasmicmalesterilityinthe1970s(first-generation)andthe“two-li ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Rice Genomics: over the Past Two Decades and into the Future
Domesticrice(OryzasativaL.)isoneofthemostimportantcerealcrops,feedingalargenumberofworldwidepopulations.Alongwithvarioushigh-throughputgenomesequencin ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Recent Advances in Function-based Metagenomic Screening
Metagenomesfromunculturedmicroorganismsarerichresourcesfornovelenzymegenes.Themethodsusedtoscreenthemetagenomiclibrariesfallintotwocategories,whichare ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
Androgenreceptor(AR)isaligand-activatedtranscriptionfactorthatplaysapivotalroleinthedevelopmentandprogressionofmanyseverediseasessuchasprostatecancer, ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
RNF126 Quenches RNF168 Function in the DNA Damage Response
DNAdamageresponse(DDR)isessentialformaintaininggenomestabilityandprotectingcellsfromtumorigenesis.Ubiquitinandubiquitin-likemodificationsplayanimporta ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
An Exome-seq Based Tool for Mapping and Selection of Candidate Genes in Maize Deletion Mutants
Despitethelargenumberofgenomicandtranscriptomicresourcesinmaize,thereisstillmuchtolearnaboutthefunctionofgenesindevelopmentalandbiochemicalprocesses.S ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Integration of A Deep Learning Classifier with A Random Forest Approach for Predicting Malonylation
Asanewly-identifiedproteinpost-translationalmodification,malonylationisinvolvedinavarietyofbiologicalfunctions.Recognizingmalonylationsitesinsubstrate ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Genome of Opium Poppy Reveals Evolutionary History of Morphinan Pathway
PDF全文下载地址:/articles/download/681 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Polyphyly in 16S rRNA-based LVTree Versus Monophyly in Whole-genome-based CVTree
Wereportanimportantbutlong-overlookedmanifestationoflow-resolutionpowerof16SrRNAsequenceanalysisatthespecieslevel,namely,in16SrRNA-basedphylogenetictr ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
VASC: Dimension Reduction and Visualization of Single-cell RNA-seq Data by Deep Variational Autoenco
Single-cellRNAsequencing(scRNA-seq)isapowerfultechniquetoanalyzethetranscriptomicheterogeneitiesatthesinglecelllevel.Itisanimportantstepforstudyingcel ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
TELS: A Novel Computational Framework for Identifying Motif Signatures of Transcribed Enhancers
Inmammaliancells,transcribedenhancers(TrEns)playimportantrolesintheinitiationofgeneexpressionandmaintenanceofgeneexpressionlevelsinaspatiotemporalmann ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
TICA: Transcriptional Interaction and Coregulation Analyzer
Transcriptionalregulationiscriticaltocellularprocessesofallorganisms.Regulatorymechanismsofteninvolvemorethanonetranscriptionfactor(TF)fromdifferentfa ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Machine Learning Models for Genetic Risk Assessment of Infants with Non-syndromic Orofacial Cleft
Theisolatedtypeoforofacialcleft,termednon-syndromiccleftlipwithorwithoutcleftpalate(NSCL/P),isthesecondmostcommonbirthdefectinChina,withAsianshavingth ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
GITAR: An Open Source Tool for Analysis and Visualization of Hi-C Data
Interactionsbetweenchromatinsegmentsplayalargeroleinfunctionalgenomicassaysanddevelopmentsingenomicinteractiondetectionmethodshaveshowninteractingtopo ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
RGAAT: A Reference-based Genome Assembly and Annotation Tool for New Genomes and Upgrade of Known Ge
Therapiddevelopmentofhigh-throughputsequencingtechnologieshasledtoadramaticdecreaseinthemoneyandtimerequiredfordenovogenomesequencingorgenomeresequenc ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
AncestryPainter: A Graphic Program for Displaying Ancestry Composition of Populations and Individual
Ancestrycompositionofpopulationsandindividualshasbeenextensivelyinvestigatedinrecentyearsduetoadvancesinthegenotypingandsequencingtechnologies.Asthenu ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
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