Ancestry composition of populations and individuals has been extensively investigated in recent years due to advances in the genotyping and sequencing technologies. As the number of populations and individuals used for ancestry inference increases remarkably, say more than 100 populations or 1000 individuals, it is usually challenging to present the ancestry composition in a traditional way using a rectangular graph. To address this issue, we developed a program, AncestryPainter, which can illustrate the ancestry composition of populations and individuals with a rounded and nice-looking graph to save space. Individuals are depicted as length-fixed bars partitioned into colored segments representing different ancestries, and the population of interest can be highlighted as a pie chart in the center of the circle plot. In addition, AncestryPainter can also be applied to display personal ancestry in a way similar to that for displaying population ancestry. AncestryPainter is publicly available at http://www.picb.ac.cn/PGG/resource.php.
近年来随着DNA测序技术的飞速发展和测序成本的持续降低,大规模地解析群体和个体的遗传背景和祖源祖源构成已成为切实可行和正在广泛开展的实践。然而,随着群体数量和样本量的持续增加,对祖源分析结果的展示,尤其是以正式发表为目标的图形展示成为一个挑战。为了全面地、一目了然地将成百上千甚至上万的群体和个体基因组的祖源清晰有效的展示在一个视野(印刷页面)上, 我们专门开发了一个新的图形化展示软件,AncestryPainter。该方法将每个个体依据祖源构成由不同颜色图形组成,所有个体紧凑排列形成一个环形,用户特别关注的群体则以饼图(Pie Chart)形式展示在环形中间,因而在最大化地节省了空间的同时更全面清晰地展示祖源分析结果。 这种展示方式可以有效的展示更多的群体的祖源构成,并且更加方便群体之间的祖源构成比较。该作图软件在http://www.picb.ac.cn/PGG/resource.php可自由下载。
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AncestryPainter: A Graphic Program for Displaying Ancestry Composition of Populations and Individual
本站小编 Free考研考试/2022-01-03
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