Esophageal squamous-cell carcinoma (ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies (GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma (CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms (SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients (survival GWAS) and gene expression (expression quantitative trait loci, eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between 8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://db.cbi.pku.edu.cn/ccgd/ESCCdb.
食管癌作为中国人群的特色肿瘤，基因组数据相对于其它肿瘤仍显不足。目前，国际上仍没有一个全面系统展现、查询的食管癌关联研究数据库。因此，我们整合分析了多种食管癌关联数据，包括（1）2022个食管癌病例和2039个正常对照的食管癌易感性全基因组关联研究；（2）1006个食管癌患者生存的全基因组关联研究；（3）94个食管癌患者的肿瘤组织和配对癌旁正常组织的遗传变异与基因表达的关联研究；（4）675个食管癌患者的体细胞变异与生存的关联研究，建立了首个食管癌关联基因数据库CCGD-ESCC，最大程度上免费共享数据资源，助力食管癌遗传学和基因组学研究。





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