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Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution
Scutellariabaicalensis(S.baicalensis)andScutellariabarbata(S.barbata)arecommonmedicinalplantsoftheLamiaceaefamily.Bothproducespecificflavonoidcompound ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
MicroRNAs Are Involved in Maize Immunity Against Fusarium verticillioides Ear Rot
Fusariumearrot(FER)causedbyFusariumverticillioidesisoneofthemostcommondiseasesaffectingmaizeproductionworldwide.FERresultsinsevereyieldlossesandgrainc ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Identification of Key Genes for the Ultrahigh Yield of Rice Using Dynamic Cross-tissue Network Analy
Significantlyincreasingcropyieldisamajorandworldwidechallengeforfoodsupplyandsecurity.Itiswell-knownthatricecultivatedatTaoyuaninYunnanofChinacanprodu ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Na2CO3-responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Reveal
Alkali-salinityexertssevereosmotic,ionic,andhigh-pHstressestoplants.Tounderstandthealkali-salinityresponsivemechanismsunderlyingphotosyntheticmodulati ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Characterization of Lysine Monomethylome and Methyltransferase in Model Cyanobacterium Synechocystis
Proteinlysinemethylationisaprevalentpost-translationalmodification(PTM)andplayscriticalrolesinalldomainsoflife.However,itsextentandfunctioninphotosynt ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles
Ubiquitination,anessentialpost-transcriptionalmodification(PTM),playsavitalroleinnearlyeverybiologicalprocess,includingdevelopmentandgrowth.Despiteits ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Genome Size Evolution Mediated by Gypsy Retrotransposons in Brassicaceae
Thedynamicactivityoftransposableelements(TEs)contributestothevastdiversityofgenomesizeandarchitectureamongplants.Here,weexaminedthegenomicdistribution ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Paleo-polyploidization in Lycophytes
Lycophytesandseedplantsconstitutethetypicalvascularplants.Lycophyteshavebeenthoughttohavenopaleo-polyploidizationalthoughtheeventisknowntobecriticalfo ...
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Genome Assembly and Pathway Analysis of Edible Mushroom Agrocybe cylindracea
Agrocybecylindracea,anediblemushroom,iswidelycultivatedforitsabundanceofnutrientsandflavor,andmanyofitsmetabolitesarereportedtohavebeneficialroles,suc ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
CircPlant: An Integrated Tool for circRNA Detection and Functional Prediction in Plants
TherecentdiscoveryofcircularRNAs(circRNAs)andcharacterizationoftheirfunctionalroleshaveopenedanewavenueforunderstandingthebiologyofgenomes.circRNAshav ...
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DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery
Toaddresstheincreasingneedfordetectingandvalidatingproteinbiomarkersinclinicalspecimens,massspectrometry(MS)-basedtargetedproteomictechniques,includin ...
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hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets
Transcriptionfactors(TFs)askeyregulatorsplaycrucialrolesinbiologicalprocesses.TheidentificationofTF–targetregulatoryrelationshipsisakeystepforrevealin ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
IRESbase: A Comprehensive Database of Experimentally Validated Internal Ribosome Entry Sites
Internalribosomeentrysites(IRESs)arefunctionalRNAelementsthatcandirectlyrecruitribosomestoaninternalpositionofthemRNAinacap-independentmannertoinitiat ...
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MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy
Mosaicvariantsresultingfrompostzygoticmutationsareprevalentinthehumangenomeandplayimportantrolesinhumandiseases.However,exceptforcancer-relatedvariant ...
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iGMDR: Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research
Currentpharmacogeneticstudieshaveobtainedmanygeneticmodelsthatcanpredictthetherapeuticefficacyofanticancerdrugs.Althoughsomeofthesemodelsareofcruciali ...
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IC4R-2.0: Rice Genome Reannotation Using Massive RNA-seq Data
Genomereannotationaimsforcompleteandaccuratecharacterizationofgenemodelsandthusisofcriticalsignificanceforin-depthexplorationofgenefunction.Althoughth ...
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SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice
Theinformationcommonsforrice(IC4R)databaseisacollectionof18millionsinglenucleotidepolymorphisms(SNPs)identifiedbyresequencingof5152riceaccessions.Alth ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
BGVD: An Integrated Database for Bovine Sequencing Variations and Selective Signatures
Next-generationsequencinghasyieldedavastamountofcattlegenomicdataforglobalcharacterizationofpopulationgeneticdiversityandidentificationofgenomicregion ...
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HybridSucc: A Hybrid-learning Architecture for General and Species-specific Succinylation Site Predi
Asanimportantproteinacylationmodification,lysinesuccinylation(Ksucc)isinvolvedindiversebiologicalprocesses,andparticipatesinhumantumorigenesis.Here,we ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SuccSite: Incorporating Amino Acid Composition and Informative k-spaced Amino Acid Pairs to Identify
Proteinsuccinylationisabiochemicalreactioninwhichasuccinylgroup(-CO-CH2-CH2-CO-)isattachedtothelysineresidueofaproteinmolecule.Lysinesuccinylationplay ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Birth of Bio-data Science: Trends, Expectations, and Applications
生物大数据，机器学习和人工智能的兴起将会改变生物学领域的研究方式。在此背景下，生物数据科学（Bio-DataScience,BDS）将会作为一门全新的学科出现。我们讨论的BDS内容包括：BDS与计算生物学和生物信息学等相关学科之间的关系；趋势和未来；培训，教育及就业方向的转变；以及BDS在实际分析中 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency
Thegenerationofinducedpluripotentstemcellsthroughsomaticcellreprogrammingrequiresaglobalreorganizationofcellularfunctions.Thisreorganizationoccursinam ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma
BRAFisaserine/threoninekinasethatharborsactivatingmutationsin～7%ofhumanmalignanciesand～60%ofmelanomas.DespiteinitialclinicalresponsestoBRAFinhibitors, ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis
Exposureofairborneparticulatematter(PM)withanaerodynamicdiameterlessthan2.5?μm(PM2.5)isepidemiologicallyassociatedwithlungdysfunctionandrespiratorysym ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Procleave: Predicting Protease-specific Substrate Cleavage Sites by Combining Sequence and Structura
Proteasesareenzymesthatcleaveandhydrolysethepeptidebondsbetweentwospecificaminoacidresiduesoftargetsubstrateproteins.Protease-controlledproteolysispla ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instabilit
Microsatelliteinstability(MSI)isakeybiomarkerforcancertherapyandprognosis.Traditionalexperimentalassaysarelaboriousandtime-consuming,andnext-generatio ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
GPS 5.0: An Update on the Prediction of Kinase-specific Phosphorylation Sites in Proteins
Ineukaryotes,proteinphosphorylationisspecificallycatalyzedbynumerousproteinkinases(PKs),faithfullyorchestratesvariousbiologicalprocesses,andreversibly ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SinoDuplex: An Improved Duplex Sequencing Approach to Detect Low-frequency Variants in Plasma cfDNA
Accuratedetectionoflowfrequencymutationsfromplasmacell-freeDNAinbloodusingtargetednextgenerationsequencingtechnologyhasshownpromisingbenefitsinclinica ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Tung Tree (Vernicia fordii) Genome Provides A Resource for Understanding Genome Evolution and Improv
Tungtree(Verniciafordii)isaneconomicallyimportantwoodyoilplantthatproducestungoilrichineleostearicacid.Here,wereportahigh-qualitychromosome-scalegenom ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Multi-omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratum
Uncoveringthefunctionallyessentialvariationsrelatedtotumorigenesisandtumorprogressionfromcancergenomicsdataisstillchallengingduetothegeneticdiversitya ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Meta-analysis Reveals Potential Influence of Oxidative Stress on the Airway Microbiomes of Cystic Fi
Thelethalchronicairwayinfectionofthecysticfibrosis(CF)patientsispredisposedbycolonizationofspecificCF-philicpathogensortheCFmicrobiomes,butkeyprocesse ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Large-scale Identification and Time-course Quantification of Ubiquitylation Events During Maize Seed
Theubiquitinsystemiscrucialforthedevelopmentandfitnessofhigherplants.De-etiolation,duringwhichgreenplantsinitiatephotomorphogenesisandestablishautotro ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Schizophrenia-associated MicroRNA–Gene Interactions in the Dorsolateral Prefrontal Cortex
Schizophrenia-associatedanomaliesingeneexpressioninpostmortembraincanbeattributedtoacombinationofgeneticandenvironmentalinfluences.Giventhesmalleffect ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
A Computational Approach for Modeling the Allele Frequency Spectrum of Populations with Arbitrarily
Theallelefrequencyspectrum(AFS),orsitefrequencyspectrum,iscommonlyusedtosummarizethegenomicpolymorphismpatternofasample,whichisinformativeforinferring ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SPOT-Disorder2: Improved Protein Intrinsic Disorder Prediction by Ensembled Deep Learning
Intrinsicallydisorderedorunstructuredproteins(orregionsinproteins)havebeenfoundtobeimportantinawiderangeofbiologicalfunctionsandimplicatedinmanydiseas ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Deep Learning Deciphers Protein–RNA Interaction
蛋白质-RNA相互作用在细胞中普遍存在，是转录后调控的主要机制。RNA结合蛋白（RBPs）通过控制多层次的基因调控，不仅控制着哪些转录物被翻译，还决定着mRNA翻译的速度、位置和浓度。碱基为主的相互作用和骨架为主的相互作用是RBPs与RNA相互作用的两种主要方式。获得蛋白质与RNA相互作用的方法主要 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening
Accurateidentificationofcompound–proteininteractions(CPIs)insilicomaydeepenourunderstandingoftheunderlyingmechanismsofdrugactionandthusremarkablyfacil ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
I3: A Self-organising Learning Workflow for Intuitive Integrative Interpretation of Complex Genetic
Weproposeacomputationalworkflow(I3)forintuitiveintegrativeinterpretationofcomplexgeneticdatamainlybuildingontheself-organisingprinciple.Weillustrateth ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression
SequencesofcircularRNAs(circRNAs)producedfromback-splicingofexon(s)completelyoverlapwiththosefromcognatelinearRNAstranscribedfromthesamegenelociwithth ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
CircAST: Full-length Assembly and Quantification of Alternatively Spliced Isoforms in Circular RNAs
CircularRNAs(circRNAs),covalentlyclosedcontinuousRNAloops,aregeneratedfromcognatelinearRNAsthroughbacksplicingevents,andalternativesplicingeventsmayge ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
shinyChromosome: An R/Shiny Application for Interactive Creation of Non-circular Plots of Whole Geno
Non-circularplotsofwholegenomesarenaturalrepresentationsofgenomicdataalignedalongallchromosomes.Currently,thereisnospecializedgraphicaluserinterface(G ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
VPOT: A Customizable Variant Prioritization Ordering Tool for Annotated Variants
Next-generationsequencing(NGS)technologiesgeneratethousandstomillionsofgeneticvariantspersample.Identificationofpotentialdisease-causalvariantsislabor ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
MakeHub: Fully Automated Generation of UCSC Genome Browser Assembly Hubs
Novelgenomesaretodayoftenannotatedbysmallconsortiaorindividualswhosebackgroundisnotfrombioinformatics.Thisaudiencerequirestoolsthatareeasytouse.Suchne ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Gclust: A Parallel Clustering Tool for Microbial Genomic Data
Theacceleratinggrowthofthepublicmicrobialgenomicdataimposessubstantialburdenontheresearchcommunitythatusessuchresources.Buildingdatabasesfornon-redund ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Challenges of Processing and Analyzing Big Data in Mesoscopic Whole-brain Imaging
随着高通量、细胞分辨全脑成像仪器的涌现，以及实验数据的迅速积累，神经科学家们开始有机会在介观水平对大脑进行全面的研究，并逐渐成为研究热点。但介观水平的全脑成像同时也带来了大数据问题，如何有效、快速的处理和分析这些研究数据，已迅速成为最关键的瓶颈问题之一。在本文中，我们首先介绍了介观水平神经科学研究的 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Deciphering Brain Complexity Using Single-cell Sequencing
Thehumanbraincontainsbillionsofhighlydifferentiatedandinterconnectedcellsthatformintricateneuralnetworksandcollectivelycontrolthephysicalactivitiesand ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Application of Computational Biology to Decode Brain Transcriptomes
Therapiddevelopmentofhigh-throughputsequencingtechnologieshasgeneratedmassivevaluablebraintranscriptomeatlases,providinggreatopportunitiesforsystemati ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
How Big Data and High-performance Computing Drive Brain Science
Brainscienceacceleratesthestudyofintelligenceandbehavior,contributesfundamentalinsightsintohumancognition,andoffersprospectivetreatmentsforbraindiseas ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Functional Neuroimaging in the New Era of Big Data
Thefieldoffunctionalneuroimaginghassubstantiallyadvancedasabigdatascienceinthepastdecade,thankstointernationalcollaborativeprojectsandcommunityefforts ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validati
Neuropsychiatricdisordersaffecthundredsofmillionsofpatientsandfamiliesworldwide.Todecodethemolecularframeworkofthesediseases,manystudiesusehumanpostmo ...
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