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Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2
Single-cellRNAsequencing(scRNA-seq)isgenerallyusedforprofilingtranscriptomeofindividualcells.Thedroplet-based10XGenomicsChromium(10X)approachandthepla ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Evaluation of Cell Type Annotation R Packages on Single-cell RNA-seq Data
Annotatingcelltypesisacriticalstepinsingle-cellRNAsequencing(scRNA-seq)dataanalysis.Somesupervisedorsemi-supervisedclassificationmethodshaverecentlyem ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SSRE: Cell Type Detection Based on Sparse Subspace Representation and Similarity Enhancement
Accurateidentificationofcelltypesfromsingle-cellRNAsequencing(scRNA-seq)dataplaysacriticalroleinavarietyofscRNA-seqanalysisstudies.Thistaskcorresponds ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
redPATH: Reconstructing the Pseudo Development Time of Cell Lineages in Single-cell RNA-seq Data and
Therecentadvancementofsingle-cellRNAsequencing(scRNA-seq)technologiesfacilitatesthestudyofcelllineagesindevelopmentalprocessesandcancer.Inthisstudy,we ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
DTFLOW: Inference and Visualization of Single-cell Pseudotime Trajectory Using Diffusion Propagation
Oneofthemajorchallengesinsingle-celldataanalysisisthedeterminationofcellulardevelopmentaltrajectoriesusingsingle-celldata.Althoughsubstantialstudiesha ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
c-CSN: Single-cell RNA Sequencing Data Analysis by Conditional Cell-specific Network
Therapidadvancementofsingle-celltechnologieshasshednewlightonthecomplexmechanismsofcellularheterogeneity.However,comparedtobulkRNAsequencing(RNA-seq), ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
scLM: Automatic Detection of Consensus Gene Clusters Across Multiple Single-cell Datasets
Ingeneexpressionprofilingstudies,includingsingle-cellRNAsequencing(scRNA-seq)analyses,theidentificationandcharacterizationofco-expressedgenesprovidesc ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage
PDF全文下载地址:/articles/download/859 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Quantitative Secretome Analysis Reveals Clinical Values of Carbonic Anhydrase II in Hepatocellular C
Earlydetectionandinterventionarekeystrategiestoreducemortality,increaselong-termsurvival,andimprovethetherapeuticeffectsofhepatocellularcarcinoma(HCC) ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Computational Screening of Phase-separating Proteins
Phaseseparationisanimportantmechanismthatmediatesthecompartmentalizationofproteinsincells.Proteinsthatcanundergophaseseparationincellssharecertaintypi ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer V
Molecular-assistedprecisiononcologygainedtremendousgroundwithhigh-throughputnext-generationsequencing(NGS),supportedbyrobustbioinformatics.Thequestfor ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
DNA Methylation Reshapes Sex Development in Zebrafish
PDF全文下载地址:/articles/download/834 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Role of DNA Methylation Reprogramming During Sex Determination and Transition in Zebrafish
DNAmethylationisaprevalentepigeneticmodificationinvertebrates,andithasbeenshowntobeinvolvedtheregulationofgeneexpressionandembryodevelopment.However,i ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lym
AlthoughDNA5-hydroxymethylcytosine(5hmC)isrecognizedasanimportantepigeneticmarkincancer,itspreciseroleinlymphnodemetastasisremainselusive.Inthisstudy, ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Global Profiling of the Lysine Crotonylome in Different Pluripotent States
Pluripotentstemcells(PSCs)canbeexpandedinvitroindifferentcultureconditions,resultinginaspectrumofcellstateswithdistinctproperties.UnderstandinghowPSCs ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZI
TheZikavirus(ZIKV)anddenguevirus(DENV)flavivirusesexhibitsimilarreplicativeprocessesbuthavedistinctclinicaloutcomes.Asystematicunderstandingofvirus–ho ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Gigantic Genomes Provide Empirical Tests of Transposable Element Dynamics Models
Transposableelements(TEs)areamajordeterminantofeukaryoticgenomesize.ThecollectivepropertiesofagenomicTEcommunityrevealthehistoryofTE/hostevolutionaryd ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes
Numerousstudiesofrelationshipbetweenepigenomicfeatureshavefocusedontheirstrongcorrelationacrossthegenome,likelybecausesuchrelationshipcanbeeasilyident ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Zhi Liu, Kai Mi, Zhenjiang Zech Xu, Qiankun Zhang, Xingyin Liu
Thedysbiosisofgutmicrobiotaisassociatedwiththepathogenesisofhumandiseases.However,observingshiftsinthemicrobeabundancecannotfullyrevealunderlyingpertu ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection Clusters
AnovelRNAvirus,thesevereacuterespiratorysyndromecoronavirus2(SARS-CoV-2),isresponsiblefortheongoingoutbreakofcoronavirusdisease2019(COVID-19).Populati ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades
COVID-19anditscausativepathogenSARS-CoV-2haverushedtheworldintoastaggeringpandemicinafewmonths,andaglobalfightagainstbothhasbeenintensifying.Here,wede ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Long Non-coding RNA Derived from lncRNA–mRNA Co-expression Networks Modulates the Locust Phase Chang
Longnon-codingRNAs(lncRNAs)regulatevariousbiologicalprocessesrangingfromgeneexpressiontoanimalbehavior.Althoughprotein-codinggenes,microRNAs,andneurop ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human D
Microbesplayimportantrolesinhumanhealthanddisease.Theinteractionbetweenmicrobesandhostsisareciprocalrelationship,whichremainslargelyunder-explored.Cur ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global P
Gastriccancer(GC)isknownasatopmalignanttypeoftumorsworldwide.Despitetherecentdecreaseinmortalityrates,theprognosisremainspoor.Therefore,itisnecessaryt ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Classification of the Gut Microbiota of Patients in Intensive Care Units During Development of Sepsi
Thegutmicrobiotaofintensivecareunit(ICU)patientsdisplaysextremedysbiosisassociatedwithincreasedsusceptibilitytoorganfailure,sepsis,andsepticshock.Howe ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Increased Expression of Colonic Mucosal Melatonin in Patients with Irritable Bowel Syndrome Correlat
Dysregulationofthegutmicrobiota/guthormoneaxiscontributestothepathogenesisofirritablebowelsyndrome(IBS).Melatoninplaysabeneficialroleingutmotilityandi ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key I
GegenQinlianDecoction(GQD),atraditionalChinesemedicine(TCM)formula,haslongbeenusedforthetreatmentofcommonmetabolicdiseases,includingtype2diabetesmelli ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
TheassociationofZikavirus(ZIKV)infectionwithmicrocephalyhasraisedalarmworldwide.TheircausallinkhasbeenconfirmedindifferentanimalmodelsinfectedbyZIKV.H ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR
OnJanuary22,2020,ChinaNationalCenterforBioinformation(CNCB)releasedthe2019NovelCoronavirusResource(2019nCoVR),anopen-accessinformationresourceforthese ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differen
Naturalkiller(NK)cellsareessentialincontrollingcancerandinfection.However,littleisknownaboutthedynamicsofthetranscriptionalregulatorymachineryduringNK ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery
Identificationofgeneticvariantsviahigh-throughputsequencing(HTS)technologieshasbeenessentialforbothfundamentalandclinicalstudies.However,towhatextentt ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Kinase–substrate Edge Biomarkers Provide A More Accurate Prognostic Prediction in ER-negative Breast
Theestrogenreceptor(ER)-negativebreastcancersubtypeisaggressivewithfewtreatmentoptionsavailable.ToidentifyspecificprognosticfactorsforER-negativebreas ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Pooled Plasmid Sequencing Reveals the Relationship Between Mobile Genetic Elements and Antimicrobial
Plasmidsremainimportantmicrobialcomponentsmediatingthehorizontalgenetransfer(HGT)anddisseminationofantimicrobialresistance.Tosystematicallyexplorether ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Exploring Potential Signals of Selection for Disordered Residues in Prokaryotic and Eukaryotic Prote
Intrinsicallydisorderedproteins(IDPs)areanimportantclassofproteinsinalldomainsoflifefortheirfunctionalimportance.However,hownaturehasshapedthedisorder ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
PIMD: An Integrative Approach for Drug Repositioning Using Multiple Characterization Fusion
Theaccumulationofvarioustypesofdruginformaticsdataandcomputationalapproachesfordrugrepositioningcanacceleratepharmaceuticalresearchanddevelopment.Howe ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
GTB-PPI: Predict Protein–protein Interactions Based on L1-regularized Logistic Regression and Gradie
Protein–proteininteractions(PPIs)areofgreatimportancetounderstandgeneticmechanisms,delineatediseasepathogenesis,andguidedrugdesign.WiththeincreaseofPP ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
iLBE for Computational Identification of Linear B-cell Epitopes by Integrating Sequence and Evolutio
LinearB-cellepitopesarecriticallyimportantforimmunologicalapplications,suchasvaccinedesign,immunodiagnostictest,andantibodyproduction,aswellasdiseased ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SeSaMe: Metagenome Sequence Classification of Arbuscular Mycorrhizal Fungi-associated Microorganisms
Arbuscularmycorrhizalfungi(AMF)areplantrootsymbiontsthatplaykeyrolesinplantgrowthandsoilfertility.Theyareobligatebiotrophicfungithatformcoenocyticmult ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
SeSaMe PS Function: Functional Analysis of the Whole Metagenome Sequencing Data of the Arbuscular My
Inthisstudy,weintroduceanovelbioinformaticsprogram,Spore-associatedSymbioticMicrobesPosition-specificFunction(SeSaMePSFunction),forposition-specificfu ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Corrigendum to “Antibiotic Treatment Drives the Diversification of the Human Gut Resistome” [Genomic
PDF全文下载地址:/articles/download/818 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes
N6-methyladenosine(m6A)isoneofthemostabundantmodificationsonmRNAsandplaysimportantrolesinvariousbiologicalprocesses.Theformationofm6Aiscatalyzedbyamet ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The mRNA Binding Proteome of Proliferating and Differentiated Muscle Cells
Muscleformationisacoordinatedprocessdrivenbyextensivegeneexpressionchangeswheresinglecellsfusetogethertoformmultinucleatedmusclefibers.Newlysynthesize ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Large-scale Proteomic and Phosphoproteomic Analyses of Maize Seedling Leaves During De-etiolation
De-etiolationconsistsofaseriesofdevelopmentalandphysiologicalchangesthataplantundergoesinresponsetolight.Duringthisprocesslight,animportantenvironment ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Transcriptomic and Proteomic Analysis of Mannitol-metabolism-associated Genes in Saccharina japonica
Asacarbon-storagecompoundandosmoprotectantinbrownalgae,mannitolissynthesizedandthenaccumulatedathighlevelsinSaccharinajaponica(Sja);however,theunderly ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Tissue-specific Gene Expression Changes Are Associated with Aging in Mice
Agingisacomplexprocessthatcanbecharacterizedbyfunctionalandcognitivedeclineinanindividual.Agingcanbeassessedbasedonthefunctionalcapacityofvitalorgansa ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Global Analysis of Gene Expression Profiles Provides Novel Insights into the Development and Evoluti
Chinesemittencrab(Eriocheirsinensis)isanimportantaquaculturespeciesinCrustacea.Functionalanalysis,althoughessential,hasbeenhinderedduetothelackofsuffi ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
The Wolfiporia cocos Genome and Transcriptome Shed Light on the Formation of Its Edible and Medicina
Wolfiporiacocos(F.A.Wolf)hasbeenpraisedasafooddelicacyandmedicineforcenturiesinChina.Here,wepresentthegenomeandtranscriptomeoftheChinesestrainCGMCC5.7 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Denoising Autoencoder, A Deep Learning Algorithm, Aids the Identification of A Novel Molecular Signa
Precisebiomarkerdevelopmentisakeystepindiseasemanagement.However,mostofthepublishedbiomarkerswerederivedfromarelativelysmallnumberofsampleswithsupervi ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
mrMLM v4.0.2: An R Platform for Multi-locus Genome-wide Association Studies
Previousstudieshavereportedthatsomeimportantlociaremissedinsingle-locusgenome-wideassociationstudies(GWAS),especiallybecauseofthelargephenotypicerrori ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
Corrigendum to “Large-scale Identification and Time-course Quantification of Ubiquitylation Events D
PDF全文下载地址:/articles/download/800 ...
中科院北京基因组研究所本站小编 Free考研考试 2022-01-03
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