The association of Zika virus (ZIKV) infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV. However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence, we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning microcephaly. We found significant dysregulation of the sub-networks associated with brain development, immune response, cell death, microglial cell activation, and autophagy amongst others. We provided detailed analysis of the related complicated gene networks and the links between them. Additionally, we analyzed the signaling pathways that were likely to be involved. This report provides systemic insights into not only the pathogenesis, but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.
寨卡病毒（ZIKV）感染与小头畸形的关联得到了全世界的关注。它们的因果关系已在ZIKV感染的动物模型和临床研究中得到证实。 但是，ZIKV导致的小头畸形发病机理的分子机制尚不清楚。 因此，我们对ZIKV感染的小鼠大脑进行了详细的全基因组表达分析，以揭示寨卡病毒导致小头畸形所涉及的生物学过程和分子网络。我们发现，与脑发育、免疫反应、细胞死亡、小胶质细胞活化和自噬等相关的分子网络严重失调。我们对相关的复杂基因网络及其之间的联系进行了深入解析。此外，我们分析了多条可能涉及的信号通路。该研究不仅对发病机理提供了系统的见解，而且还将为开发针对ZIKV感染的预防和治疗提供重要的策略。





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