删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

本站小编 Free考研考试/2022-01-03

鎴愪负璇句唬琛紝鍒嗕韩璇剧▼璧勬枡閾炬帴灏辫兘鑾峰彇40%鎻愭垚璧氶挶锛�
鎺ㄥ箍璧氶挶鏉冪泭銆傝浠h〃鍙€氳繃浜掕仈缃戠瓑閫斿緞涓烘湰绔欐帹骞垮浼犫€淰IP浼氬憳鈥濓紝鐢ㄦ埛閫氳繃璇句唬琛ㄧ殑鍒嗕韩閾炬帴鎴栨捣鎶ヨ喘涔板悗锛岃浠h〃鑾峰彇40%鎻愭垚銆傝浠h〃璐拱鏈珯浠讳綍浜у搧锛屽潎浜彈9鎶樸€傚皢鍒嗕韩閾炬帴銆佹捣鎶ュ浘鐗囩瓑锛屽彂鍒板鏍¤鍧涖€佺櫨搴﹁创鍚с€佸井鍗氥€佸井淇°€丵Q绌洪棿銆佺煡涔庛€佽眴鐡g瓑鍚勫ぇ骞冲彴銆�
Aging is a complex process that can be characterized by functional and cognitive decline in an individual. Aging can be assessed based on the functional capacity of vital organs and their intricate interactions with one another. Thus, the nature of aging can be described by focusing on a specific organ and an individual itself. However, to fully understand the complexity of aging, one must investigate not only a single tissue or biological process but also its complex interplay and interdependencies with other biological processes. Here, using RNA-seq, we monitored changes in the transcriptome during aging in four tissues (including brain, blood, skin and liver) in mice at 9 months, 15 months, and 24 months, with a final evaluation at the very old age of 30 months. We identified several genes and processes that were differentially regulated during aging in both tissue-dependent and tissue-independent manners. Most importantly, we found that the electron transport chain (ETC) of mitochondria was similarly affected at the transcriptome level in the four tissues during the aging process. We also identified the liver as the tissue showing the largest variety of differentially expressed genes (DEGs) over time. Lcn2 (Lipocalin-2) was found to be similarly regulated among all tissues, and its effect on longevity and survival was validated using its orthologue in Caenorhabditis elegans. Our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue’s specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.






PDF全文下载地址:

http://gpb.big.ac.cn/articles/download/795
相关话题/gen