摘要/Abstract

探索了在布朗斯特酸和路易斯酸作用下，以1，4-二氧六环为溶剂，由三氟丙酮酸乙酯、酰肼、烯丙基溴和锡粉在回流条件下一锅法合成α-三氟甲基高烯丙基酰肼的方法.该方法避免了使用有毒的有机锡试剂，并且操作简单，反应条件温和，以良好的收率得到其相应的产物.
关键词: 一锅法, 锡粉, 三氟丙酮酸乙酯, α-三氟甲基高烯丙基酰肼
An efficient multicomponent one-pot reaction was developed for the synthesis of α-trifluoromethyl homoallylic hydrazides from the reactions of ethyl trifluoropyruvate, hydrazides and allylic bromide with tin powder in the presence of Brønsted and Lewis acid in 1,4-dioxane under reflux. The method avoids the use of toxic stannanes and allows easy operation. The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.
Key words: one-pot, tin powder, ethyl trifluoropyruvate, α-trifluoromethyl homoallylic hydrazides


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