摘要/Abstract

以苯硫酚为还原剂，在绿色溶剂、室温下将α，α，α-三溴甲基酮类化合物还原成α，α-二溴甲基酮类化合物.此反应适用于芳香族、脂肪族和杂环类α，α，α-三溴甲基酮类化合物，产率高达97%.进一步的机理研究表明，该反应是自由基反应.
关键词: 苯硫酚, α,α-二溴甲基酮, 绿色合成, 还原反应
α,α-Dibromomethyl ketones were synthesized with high yields through a thiophenol-promoted reduction of α,α,α-tribromomethyl ketones under mild conditions within one hour. A further mechanistic study showed that the reaction proceeded via a radical process. This is an example that uses thiophenol as the radical stimulator in the reduction of multi-halogenated compounds.
Key words: thiophenol, α,α-dibromomethyl ketones, green synthesis, reduction


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