摘要/Abstract

为寻找具有高杀菌活性的农药先导化合物，采用活性亚结构拼接的方法，将吡唑醚菌酯结构中羟基吡唑结构片段引入氟唑菌酰羟胺的结构中，合成了12个结构新颖的N-烷氧基酰胺类化合物.目标化合物的结构经过¹H NMR，¹³C NMR和HRMS确证.杀菌活性测试表明，在测试浓度下，一些目标化合物对亚洲大豆锈病、黄瓜霜霉病或黄瓜白粉病表现出了一定的防效，其中化合物3a在100 mg/L测试浓度下对黄瓜白粉病的防效为95%.
关键词: 氟唑菌酰羟胺, 酰胺, 农药, 杀菌活性
In order to find lead compounds with high fungicidal activity, the phenyl moiety of pydiflumetofen was replaced by substituted 1-phenyl-3-hydroxylpyrazole moiety of pyraclostrobin according to the method of active substructure combination. 12 novel N-alkoxyl amides were synthesized and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. Preliminary fungicidal activity screening results showed that some analogues exhibited certain fungicidal activity against Phakopsora pachyrhizi, Pseudoperonospora cubensis or Erysiphe cichoracearum, compound 3a displayed 95% protective effect against Erysiphe cichoracearum at 100 mg/L.
Key words: pydiflumetofen, amide, pesticide, fungicidal activity


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