摘要/Abstract
报道了一种醋酸钯催化N,N-二甲基甲酰胺(DMF)与各类胺高效合成甲酰胺化合物的方法.该反应体系简单,具有催化效率高,不需要其它溶剂及共催化剂,底物普适范围广的优点,为合成甲酰胺化合物提供了一种快速,实用的方法.
关键词: 醋酸钯, N,N-二甲基甲酰胺(DMF), 胺, N-甲酰化
A highly efficient protocol for the transamidation of N,N-dimethylformamide (DMF) and amines has been developed, utilizing a catalytic amount Pd(OAc)2. This methodology has a broad substrate scope for aliphatic, aromatic, and heterocyclic amines. And this process is simple and easily performed without solvent and co-catalyst.
Key words: Pd(OAc)2, N,N-dimethylformamide (DMF), amines, N-formylation
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