摘要/Abstract
构筑碳-氮键在有机合成和药物化学领域有着重要的意义.近年来关于碳氮键合成反应的研究取得了长足的进展.其中铜催化的Chan-Lam偶联反应是构筑碳氮键最有效和直接的方式之一.系统综述了近十多年Chan-Lam偶联反应直接构筑C-N键的催化机理、反应体系、底物范围及结构特点等.
关键词: Chan-Lam偶联反应, 铜催化, C-N键, 芳基硼酸, 含氮化合物
Construction of C-N bond is one of the most important areas in synthetic organic chemistry and medical chemistry. Many synthetic methods for the construction of C-N bond have been reported over the past few years. Copper-catalyzed Chan-Lam reactions represent one of the most powerful and straightforward tools to construct C-N bonds. In this paper, the recent progress in Chan-Lam coupling of N-compounds with (hetero) aryl boronates to construct C-N bond based on the reaction mechanism, reaction system, the scope of substrates, etc., is reviewed.
Key words: Chan-Lam coupling, copper-catalyzed, C-N bond, aryl boronates, N-compounds
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