摘要/Abstract
具有不同拓扑结构的聚酰胺胺是基因载体和药物传递的理想选择.报道了一系列具有相同重复单元，但是支化度不同的聚酰胺胺.通过N，N-亚甲基二（丙烯酰胺）（MBA）和L-半胱氨酸甲酯盐酸盐（CYS）在水/二甲基亚砜的共溶剂中的Michael加成缩聚反应，成功地制备出了不同支化度的聚酰胺胺.制备的阳离子聚酰胺胺（PAAs）具有良好的DNA复合能力.
关键词: 聚酰胺胺, 支化聚合物, 基因载体, L-半胱氨酸甲酯盐酸盐, 环糊精
Poly (amido amine)s with diverse topographical structures are promising candidates for gene delivery and drug carriers. A series of poly (amido amine)s (PAAs) with the same repeating units, however, different degree of branching, were successfully prepared by Michael addition polycondensation of N,N-methylenebis (acrylamide) (MBA) and L-cysteine methyl ester hydrochloride (CYS) in a water/dimethyl sulfoxide co-solvent. The obtained disposed cationic PAAs exhibit good DNA condensation capacities.
Key words: poly(amido amine)s, branched polymer, gene delivery, L-cysteine methyl ester hydrochloride, cyclodextrin
PDF全文下载地址:
点我下载PDF
