摘要/Abstract

使用了核磁共振波谱、基质辅助激光解吸电离飞行时间质谱、等温滴定量热和荧光光谱等表征手段考察了对称四甲基六元瓜环（TMeQ[6]）与抗癌性药物分子卡培他滨（CAP）之间的主客体超分子作用，实验结果表明：CAP分子的烷基链部分进入到了瓜环的空腔内部，而其余的部分则处于瓜环的端口外侧.该结论为今后TMeQ[6]在医学领域上作为药物分子载体方面的应用提供了理论依据.
关键词: 超分子, 主客体, 瓜环, 卡培他滨, 自组装
A novel supramolecular host-guest complex of the anticancer drug capecitabine (CAP) with symmetrical α, α',δ, δ'-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetryand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research ?elds.
Key words: supramolecular, host-guest, cucurbit[n]uril, capecitabine, self-assembly


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