摘要/Abstract

为了寻找具有较好生物活性的吡唑肟类衍生物，采用活性基团拼接方法，设计合成了一系列新型含取代噁二唑结构的吡唑肟类化合物.利用¹H NMR、¹³C NMR和元素分析等手段确证了目标化合物的结构.初步的生物活性测试结果表明，部分目标化合物显示出较好的杀虫活性.当测试浓度降为100 μg/mL时，3个化合物对粘虫仍具有较好的杀虫效果，杀死率分别为70%，60%和70%.另外，1个化合物在测试浓度为500 μg/mL时对蚜虫也表现出一定的杀虫作用，杀死率为60%.
关键词: 噁二唑, 吡唑肟, 合成, 生物活性
In order to find novel pyrazole oximes with good bioactivities, a series of novel pyrazole oxime derivatives containing substituted oxadiazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data indicated that some title compounds showed good insecticidal activities. At the concentration of 500 μg/mL, 9 compounds possessed insecticidal activity against Oriental armyworm with 80%~100%. When the concentration was lowered to 100 μg/mL, 3 compounds still displayed significant insecticidal activity against Oriental armyworm with 70%, 60% and 70%. Additionally, one compound had 60% insecticidal activity against Aphis medicaginis at 500 μg/mL.
Key words: oxadiazole, pyrazole oxime, synthesis, biological activity


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