摘要/Abstract
综合运用多种现代色谱学分离方法对黎药胆木中的化学成分进行了研究，从其枝叶的乙醇提取物中分离得到了4个吲哚生物碱类化合物，采用多种现代波谱技术确定了这些化合物的化学结构，分别鉴定为：nauclofficine（1）、naucleamide A（2）、naucleamide D（3）和latifoliamide A（4）.其中化合物1为一个新生物碱，化合物2～4为首次从胆木中分离得到的化合物.化合物1～4的体外细胞毒活性评价结果表明，它们对5种肿瘤细胞株（HL-60、A549、SMMC-7721、MCF-7和SW480）均显示出了较为显著的体外生长抑制活性，细胞毒活性与抗肿瘤阳性对照药顺铂的活性相当.
关键词: 乌檀属, 胆木, nauclofficine, 细胞毒活性
A new indole alkaloid, nauclofficine (1), together with three known alkaloids, naucleamide A (2), naucleamide D (3) and latifoliamide A (4), were isolated from the stems and leaves of Nauclea officinalis. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from N. officinalis for the first time. The cytotoxicities of compounds 1~4 were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Research results showed that compounds 1~4 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.
Key words: Nauclea, Nauclea officinalis, nauclofficine, cytotoxicities
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