摘要/Abstract
选用甘氨酸等当体镍螯合物与α，β-不饱和酮进行不对称Michael加成反应，在室温条件下，以1，8-二氮杂二环十一碳-7-烯（DBU）为碱，甲醇为溶剂，不对称合成了3，5-二取代脯氨酸及其衍生物.该方法具有操作简单、收率高、底物适用范围广的特点，为3，5-二取代脯氨酸及其衍生物的不对称合成提供了新的研究思路.
关键词: 3,5-二取代脯氨酸, 甘氨酸等当体镍螯合物, 不对称Michael加成反应
Highly diastereoselective Michael addition reactions of chiral Ni(Ⅱ)-complex of glycine with α,β-unsaturated ketones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and MeOH at ambient temperature were achieved. The operationally convenient procedure for preparation of the target products renders that this method is an attractive strategy for practical synthesis of 3,5-disubstituted prolines.
Key words: 3,5-disubstituted proline, Ni (II)-complex of glycine, asymmetric Michael addition
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