摘要/Abstract

以核糖核苷为原料，通过糖环的结构转化合成了系列吗啉核苷类似物，再与磺胺类药物的母核偶联得到吗啉核苷磺胺衍生物.所得化合物均经HRMS、¹H NMR和¹³C NMR谱分析确证.以牛病毒性腹泻病毒（BVDV）感染的牛肾细胞为模型对目标化合物抗病毒活性进行筛选，结果显示此类化合物无明显抗病毒活性.
关键词: 核苷类似物, 吗啉核苷, 磺胺类衍生物, 抗BVDV活性
A series of morpholine nucleoside analogues were synthesized starting from ribonucleosides, and then the morpholine nucleoside sulfonamide derivatives were obtained by treated with N-acetylsulfanilyl chloride. The obtained compounds were confirmed by HRMS, ¹H NMR and ¹³C NMR spectral analysis. The bovine kidney cells infected with bovine viral diarrhea virus (BVDV) were used as models to screen the antiviral activity of the target compounds. But the results did not show desired potent antiviral activity.
Key words: nucleoside analogue, morpholine nucleoside, sulfonamides derivative, anti-BVDV activity


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