摘要/Abstract

以薯蓣皂苷元为先导物，设计并合成了9个新的薯蓣皂苷元含氮衍生物，其结构经过¹H NMR，¹³C NMR，IR和HRMS鉴定.所有衍生物采用噻唑蓝（MTT）法进行抗肿瘤活性（A549，A431，H1975，HCT-116，Aspc-1，Ramos）的测定以及细胞毒性（HBE，LO-2）的研究.研究结果表明，大部分薯蓣皂苷元衍生物具有显著的抗肿瘤活性和低细胞毒性.
关键词: 薯蓣皂苷元, 衍生物, 抗肿瘤活性, 酰胺
Nine novel diosgenin derivatives were designed and synthesized by using diosgenin as a precursor. Their structures were identified by ¹H NMR, ¹³C NMR, IR and HRMS. Antitumor activity (A549, A431, H1975, HCT-116, Aspc-1, Ramos) and cytotoxicity (HBE, LO-2) were measured for all derivatives using thiazolyl blue tetrazolium bromide (MTT). The results show that most diosgenin derivatives have significant anti-tumor activity and low cytotoxicity.
Key words: diosgenin, derivative, antitumor activity, amide


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