摘要/Abstract

开发了一种以分子碘为氧化剂、无过渡金属参与的2-氨基吡啶对α，β-不饱和酮的双胺化反应.该方法不仅可以合成3-酰基咪唑并[1，2-a]吡啶，而且通过改变反应溶剂和底物2-氨基吡啶上的取代基还可以选择性地合成结构新颖的2-酰基咪唑并吡啶衍生物.
关键词: 分子碘, 无过渡金属, 双胺化, 咪唑并[1,2-a]吡啶, 区域选择性
Employing molecular iodine as the sole oxidant, a new and transition metal-free diamination reaction of α,β-unsaturated ketones with 2-aminopyridines has been developed. It can not only produce 3-acyl imidazo[1,2-a]pyridines but can also generate novel 2-acyl derivatives regioselectively by changing the solvent and substituents in the 2-aminopyridine substrates.
Key words: molecular iodine, transition metal-free, diamination, imidazo[1,2-a]pyridine, regioselective


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