摘要/Abstract

以α-活性亚甲基腈和2，5-二羟基-1，4-二噻烷为原料，通过爪哇毛霉脂肪酶催化的Gewald反应合成了一系列2-氨基噻吩类化合物.该方法与传统的化学催化方法相比，具有反应条件温和、催化剂可生物降解、底物适用范围较宽泛等优点.
关键词: α-活性亚甲基腈, 2,5-二羟基-1,4-二噻烷, 脂肪酶, Gewald反应, 2-氨基噻吩
A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2,5-dihydroxy-1,4-dithiane using amano lipase M from Mucor javanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.
Key words: α-active methylene nitrile, 2,5-dihydroxy-1,4-dithiane, lipase, Gewald reaction, 2-aminothiophene


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