摘要/Abstract
探索了路易斯酸催化下，通过三氟甲基酰腙和烯烃的[3+2]环加成反应来合成三氟甲基取代的吡唑烷类化合物的方法.该方法使用廉价易得的三氟甲基酰腙作为三氟甲基合成砌块，具有反应条件温和，产物的产率高等优点.而且，通过该环加成反应得到的三氟甲基吡唑烷类化合物可以很容易地被转化为三氟甲基取代的吡唑啉类化合物.
关键词: 三氟甲基合成砌块, 环加成, 三氟甲基酰腙, 烯烃, 三氟甲基吡唑烷, 三氟甲基吡唑啉
A Lewis acid-catalyzed[3+2] cycloaddition of trifluoromethylated N-acylhydrazones with alkenes was explored, and a series of CF3-substituted pryazolidines were obtained in high yields (up to 91%). The reaction features the use of cheap and readily available trifluoromethylated N-acylhydrazones as trifluoromethyl building blocks, mild reaction conditions and easy operation. Furthermore, the cycloadducts can be transformed into trifluoromethylated pyrazolines in excellent yields.
Key words: trifluoromethyl building blocks, cycloaddition, trifluoromethylated N-acylhydrazones, alkenes, trifluoromethyl pyrazolidines, trifluoromethyl pyrazolines
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