摘要/Abstract
在Pd/O2体系中,邻炔基苯乙烯类衍生物经过氯钯化/Heck偶联多步串联反应,获得了13个3位氯取代茚类化合物.该方法以氧气为唯一氧化剂,以氯化锂为氯源,避免了过量氯化铜的加入,具有绿色环保、条件温和、产率高和底物普适性较好等特点.
关键词: 钯催化, 氧气, 氯钯化, 茚
An economic and environmental synthestic method for 3-chloroindenes from o-(alkynyl)styrenes through tandem reactions including choropalladation/Heck cross coupling in Pd/O2 system was reported. Taking green dioxygen as sole oxidant and LiCl as chlorine source, 13 functionalized 3-chloroindenes could be synthesized in moderate to high yield without the addition of CuCl2
Key words: Pd-catalyzed, dioxygen, chloropalladation, indene
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