摘要/Abstract
以含有内酯结构单元的苯胺类衍生物为原料,通过自由基正离子盐促进的饱和C-H键需氧氧化,与苯乙烯类化合物发生氧化Povarov反应,实现了含内酯结构单元的喹啉衍生物的高效合成,为含有多官能团的喹啉骨架的建立提拱了新方法.机理研究表明,该反应中饱和C-H键的氧化是通过自由基中间体实现的.
关键词: 自由基正离子盐, 碳氢活化, Povarov反应, 喹啉, 内酯
Using aniline derivatives containing lactone structure and styrenes as the starting materials, a series of lactone substituted quinolines were constructed efficiently by oxidative Povarov reaction, promoted by radical cation salt. This reaction provides a new method to achieve the construction of functionalized quinoline skeletons. The mechanistic study reveales that the oxidation of the saturated C-H bond is mediated by free radical intermediate.
Key words: radical cation salt, C-H activation, Povarov reaction, quinoline, lactone
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