摘要/Abstract

探索了锡粉促进下，靛红或α-羰基酯与2-（溴甲基）丙烯酸乙酯的“一锅法”反应，得到了一系列含有螺环氧化吲哚结构单元的或γ，γ-二取代的α-亚甲基-γ-丁内酯衍生物.该方法避免了使用有毒的有机锡试剂，具有反应条件温和、操作简单、产率高等优点，为合成α-亚甲基-γ-丁内酯衍生物提供了一种有效的新方法.
关键词: 一锅法, 锡粉, 靛红, 2-(溴甲基)丙烯酸乙酯, α-亚甲基-γ-丁内酯, 螺环氧化吲哚-γ-丁内酯
An one-pot reaction of various isatin compounds or α-keto esters and ethyl 2-(bromomethyl)acrylate promoted by tin powder has been investigated, affording the corresponding isatin-derived spirocyclic α-methylene-γ-butyrolactones or γ, γ-disubstituted α-methylene-γ-butyrolactones in high yields. The method uses the combination of tin powder and ethyl 2-(bromomethyl)acrylate to replace the corresponding toxic stannanes and allows the operation much easier.
Key words: one-pot, tin powder, isatin, 2-(bromomethyl)acrylate, α-methylene-γ-butyrolactone, spirooxindole-γ-butyrolactone


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