摘要/Abstract
研究了铜促进的8-酰氨基喹啉类化合物的N-芳基化反应.在40 mol% Cu（OAc）2，2.0 equiv.NaHCO3作用下，1，4-二氧六环为溶剂，100℃下，8-酰氨基喹啉与三芳基铋发生N-芳基化反应，以中等至较高产率得到目标产物.该反应具有良好的底物普适性，为N-芳基酰胺类化合物的合成提供了一种新的方法.
关键词: 铜, 芳基化反应, 8-酰氨基喹啉, 三芳基铋
A copper-promoted N-arylation of 8-acylaminoquinolines has been developed. The N-arylation of 8-acylaminoquinoline with triaryl bismuth generated the target products in moderate to high yields under 40 mol% Cu(OAc)2, 2.0 equiv. of NaHCO3 in 1, 4-dioxane at 100 ℃ for 12 h. The reaction is compatible with a wide range of quinoline substrates, which provides a new method for synthesis of N-arylamide compounds.
Key words: copper, arylation, 8-acylaminoquinoline, triaryl bismuth
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