摘要/Abstract

自从有机硼试剂问世以来，它在有机合成领域展示了强大的功能.特别是现代合成方法的迅速发展，以钯、镍、铑等过渡金属催化的各种偶联反应极大地推动了有机硼试剂的应用，其中最令人熟知的是Suzuki偶联反应.2，4，6-三甲基苯硼酸由于其显著的位阻和电子效应，广泛参与各种偶联反应（包括Suzuki偶联、芳基碳氢键活化、羰基化、去羰基化、光氧化还原及其他碳杂键的偶联），被用于合成配体、药物及各种功能材料等.以它为研究对象，对其参与的偶联反应进行了详细的分类及综述，并提出了自己的观点并进行展望.
关键词: 2,4,6-三甲基苯硼酸, 偶联反应, C-H活化, 合成
Organic boronic reagents have played a critical role in the field of organic synthesis, especially Suzuki coupling, since they were founded. In return, all kinds of transition metal (Pd, Ni, Rh, Au etc.)-catalyzed coupling reactions have given a big push for the development and application of organic boronic reagents. 2,4,6-Mesitylboronic acid was used widely in various coupling reactions, including Suzuiki reaction, aromatic C-H activation, oxidative Heck reaction, carbonlation, decarboxylation, photoredox reaction and other C-X (C-N, C-S, C-Se) bonding reaction, which was used to synthesize functional materials, ligands and drug molecules. This paper includes two aspects:(1) reviewing the application of mesityl boronic acid and its ester in coupling reaction, and (2) making our points and respecting for this field.
Key words: mesitylboronic acid, coupling reaction, C-H activiation, synthesis


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