摘要/Abstract

含有碳-氮（C-N）键的胺类化合物广泛存在于天然产物、药物分子和功能材料之中.C-N键作为分布最广且相对惰性的化学键之一，通过对其选择性的断裂来构建新的碳-碳（C-C）或碳-杂（C-X）键在近年来逐渐发展为一种新的合成方法.季铵盐化合物易于从胺类化合物合成，发生C-N键断裂相对容易.综述了近年来以季铵盐为原料通过过渡金属催化的C-N键断裂实现的交叉偶联反应.
关键词: 过渡金属催化, 季铵盐, 交叉偶联反应, C-N键断裂
Amines containing carbon-nitrogen (C-N) bonds are widely distributed in natural products, drug molecules and functional materials. C-N bonds are one of the most abundant and inert bonds in organic molecules. Selective cleavage of C-N bonds to construct carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds represents a new synthetic method in organic synthesis. It is difficult for the direct cleavage of C-N bond. Ammonium salts are a series of stable compounds easily obtained from amines. The recent progress of transition-metal-catalyzed cross-coupling reactions via C-N bond cleavage using ammonium salts as starting materials is summerized.
Key words: transition-metal-catalysis, ammonium salt, cross-coupling reaction, C-N bond cleavage


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