摘要/Abstract
N-乙烯基唑化合物因其优异的生物活性，是医药、农药等领域中重要的活性中间体.以唑类化合物为原料，2，3-二溴丙酸甲酯为Michael受体，近室温无金属催化合成了22种具有反式烯烃基团的N-乙烯基唑化合物，其中包括15种新化合物.研究表明，该反应条件温和，普适性好，能够高效合成立体选择性的N-乙烯基唑化合物.
关键词: 无金属, C—N偶联, 烯基化, 唑类, 立体选择性
A metal-free synthetic protocol for N-vinylazoles has been developed. Twenty-two structurally diversed N-vinylazoles including 15 new compounds are obtained with good to high yield at near room temperature, and all of products consist trans-alkene moieties with high stereoselectivity.
Key words: metal-free, C—N coupling, vinylation, azoles, stereoselectivity
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