摘要/Abstract

与化学催化或酶催化合成相比，化学-酶相结合的多步串联反应是一种更简单、高效、经济的方法，兼具酶催化剂的高效、高选择性等优点，且合成原料价廉易得，合成工艺简捷高效，生产环境绿色友好，所得产品光学纯度高，使其在高附加值手性化合物的开发和合成方面得到了广泛的应用.近年来，化学家们通过改变催化剂和设计更为合理的反应方式，致力于将化学-酶催化反应条件变得更为容易，从而将其应用于更多反应领域.综述了近年来国内外化学-酶多步串联反应，如酶与金属催化、酶与有机催化、酶与新型反应技术等相结合多步串联合成手性醇类、环氧类、杂环类以及其他手性化合物的研究进展，并对该领域的发展趋势进行了展望.
关键词: 化学-酶, 串联反应, 高附加值手性化合物, 酶-金属催化, 酶-有机催化
Compared with traditional chemical catalysis or enzymatic synthesis, chemoenzymatic relay reaction is a simpler, more efficient and economical method. It not only has the advantages of high efficiency and selectivity of enzyme catalysis, but also has the advantages of low price of synthetic raw materials, simple and high efficiency of synthetic process, green and friendly production environment, and excellent optical purity of the obtained product. Thus, chemoenzymatic relay synthesis methods have been widely used in the synthesis of high-value chiral compounds. In recent years, chemists have been committed to making chemoenzymatic catalytic conditions easier by changing catalysts and designing more reasonable ways, which could be used in more fields. In this review, the recent progress in the synthesis of chiral alcohols, epoxides, heterocyclics and other chiral compounds by using chemoenzymatic relay synthesis, such as enzyme and metal catalysis, enzyme and organic catalysis, enzyme and new reaction techniques, is reviewed, and the development trends of this field are also prospected.
Key words: chemoenzymatic, relay reaction, high-value chiral compound, enzyme-metal catalysis, enzyme-organic catalysis


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