摘要/Abstract

含有三氟甲基基团的有机分子中常常表现出独特的物理和化学性质，具有非常广泛的应用.三氟乙酸及其衍生物具有廉价、易得、稳定等优点，并且反应的副产物是二氧化碳，是理想的三氟甲基化试剂，具有广阔的应用前景.综述了以三氟乙酸及其衍生物为三氟甲基源的三氟甲基化反应的最新研究进展，主要包括C-X （X=Br，I）键、C-H键，C=X （X=C，O）的三氟甲基化反应，对反应的相关机理进行了论述.
关键词: 三氟乙酸, 氟化学, 氟, 三氟乙基化, 碳氢键活化
Organic molecules containing trifluoromethyl groups often exhibit unique physical and chemical properties, and have found extensive applications. Trifluoroacetic acid and its derivatives have advantages including low cost, ready availability and high stability. Furthermore, CO₂ is the byproduct. Therefore, trifluoroacetic acid and its derivatives are ideal trifluoromethylating reagents, and have great application potentials. The progress of trifluoromethylation reactions using trifluoroacetic acid and its derivatives as CF₃-sources is reviewed, including the reactions of C-X (X=Br and I), C-H, and C=X (X=C, O). The mechanisms are also introduced.
Key words: trifluoroacetic acid, CF₃-sources, trifluoromethylation reaction, C-H activation


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