摘要/Abstract

邻亚甲基苯醌化合物是一类非常活泼和重要的中间体，被广泛应用于天然产物和药物化学中.以2-[羟基（苯基）甲基]苯酚类化合物和胺为原料，1，2-二氯乙烷为溶剂，在Sc（Ⅲ）促进下原位生成邻亚甲基苯醌，并发生氮杂迈克尔加成反应合成贝蒂碱衍生物.反应在封管条件下90℃搅拌4 h完成，以76%~96%的产率得到目标产物.
关键词: 邻亚甲基苯醌, 贝蒂碱, 氮杂迈克尔加成反应, 绿色化学
o-Quinone derivatives are not only a variety of active and important intermediate, but also widely used in the synthesis of natural products and medicinal chemistry. In the present study, the Sc(Ⅲ) catalyzed aza-Michael addition to o-quinone methides by amines for the synthesis of Betti base derivatives was developed. The reaction was performed in a sealed tube at 90℃ for 4 h and the products were obtained in moderate to good yields (76%~96%).
Key words: o-quinone, Betti base, aza-Michael addtion, green chemistry


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