摘要/Abstract

三氟甲基取代的三氮唑及四氮唑化合物在药物、农药、催化及材料等领域发挥着越来越重要的作用，其合成方法也日益受到重视.对近10年来三氟甲基三氮唑及四氮唑化合物的合成方法研究进展进行了分类归纳总结，着重展示了三氟甲基炔烃、三氟乙酰基衍生物、三氟甲基吡喃酮及三氟重氮乙烷等含氟砌块在这两类杂环合成中的应用.
关键词: 三氟甲基, 三氮唑, 四氮唑, 含氟杂环, 环加成反应
Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF₃-containing molecules. Herein, the advances in the past decade towards the synthesis of CF₃-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF₃-functionalized building blocks including CF₃-containing alkynes, CF₃-containing carbonyl compounds, CF₃-containing pyrones and trifluorodiazoethane (CF₃CHN₂) is demonstrated accordingly.
Key words: trifluoromethyl group, triazole, tetrazole, fluorine-containing heterocycle, cycloaddition


PDF全文下载地址:

点我下载PDF