摘要/Abstract

报道了一种以简单、易得的氯化铵为胺源，合成伯酰胺的酰胺化方法.以N-甲基吡咯烷酮（NMP）为溶剂和缚酸剂，在加热的条件下各种脂肪酰氯和芳香酰氯都能与氯化铵快速地反应，以良好到优秀的收率得到相应的伯酰胺，该反应为伯酰胺的合成提供了一种快速、实用的方法.
关键词: 铵盐, 酰胺化, 伯酰胺, 酰氯, N-甲基吡咯烷酮
A practical amidation reaction for the synthesis of primary amides is presented, in which the simple NH₄Cl was identified as a practical and convenient amine source. A series of aromatic and aliphatic acid chlorides were successfully compatible with this protocol, affording the corresponding amides in good to excellent yields, which provides a rapid and reliable approach to amides from simple starting materials. Introducing the appropriate N-methyl pyrrolidone (NMP) into the system as solvent and acid-binding reagent plays a key role to avoid the use of stoichiometric amounts of base.
Key words: ammonium salts, amidation, primary amides, acid chlorides, N-methyl pyrrolidone


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