摘要/Abstract

以氟代双（苯磺酰基）甲烷为氟化试剂，AgF（3 mol%）为催化剂，实现了9-联烯嘌呤的单氟甲基化反应，并在不同取代基的9-联烯嘌呤底物中均表现出了较好的收率.单氟甲基化反应具有较高的化学选择性和E-选择性.同时，这种方法为合成含氟嘌呤化合物提供了一种有效的途径.
关键词: 单氟甲基化反应, 9-联烯嘌呤, 氟代双(苯磺酰基)甲烷
The monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane has been achieved. With AgF (3 mol%) as the catalyst, the fluorobis(phenylsulfonyl)methylated adducts could be afforded in excellent yields. The monofluoromethylation exhibited high chemoselectivities and E-selectivies. Meanwhile, the monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane provided a useful route to construct fluorinated acyclic nucleoside analogues.
Key words: monofluoromethylation, purin-9-yl allene, fluorobis(phenylsulfonyl)methane


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