摘要/Abstract
新型双功能伯胺-方酰胺能有效催化醛与马来酰亚胺的不对称Michael加成反应.应用此法，可简便地制备一系列取代的琥珀酰亚胺衍生物，并能以高产率（高达98%）和优秀的对映选择性（高达>99%ee）分别得到相应加成产物的两个异构体.
关键词: 伯胺-方酰胺, 有机催化, Michael加成, 醛, 马来酰亚胺, 琥珀酰亚胺衍生物
The asymmetric Michael addition reaction of α,α-disubstituted aldehydes to maleimides catalyzed by new bifunctional primary amine-squaramides has been developed. This organocatalytic asymmetric reaction provides easy access to functionalized succinimides with a broad substrate scope. Both enantiomers of desired succinimide derivatives were obtained in good to excellent yields (up to 98%) with excellent enantioselectivities (up to >99% ee )
Key words: primary amine-squaramide, organocatalysis, Michael addition, aldehyde, maleimide, succinimide derivative
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