xm:杨玉社
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:ysyang@simm.ac.cn
grzy:
zjlb:研究员；新药；
zw:课题组长、博士生导师
txdz:上海市浦东新区祖冲之路555号
grjj:杨玉社博士1996年在中国科学院上海药物研究所获得博士学位，现任中科院上海药物研究所研究组长、博士生导师、二级研究员。研究领域为抗菌药物，肿瘤药物，抗凝血药物以及药物合成新工艺、新方法，积累了丰富的创新药物研究、开发经验。2009年成功研制出我国第一个具有自主知识产权的氟喹诺酮新药盐酸安妥沙星。近年来主持多项国家新药创制重大专项，自然科学基金，上海市科委新药重点课题，3个1.1类新药转让给企业开发。在J.Med.Chem., J.Org.Chem., Bioorg.Med. Chem. Lett., Eur.J. Med.Chem.等杂志发表论文67篇，申请国内、国际专利47项，授权20余项，其中多项专利转让给国内大型企业实施。新药产业化取得重大成绩，获得国家1.1类新药证书2个，二类新药证书8个。

教育经历

9/1/1983-8/1/1987，四川大学，化学学士学位

9/1/1987-8/1/1990，四川大学，有机化学硕士学位

9/1/1993-8/1/1996，中国科学院上海药物研究所，有机化学/药物化学博士学位

9/1/1996-8/1/1998，中国科学院上海药物研究所，博士后

yjfx:1.基于知识的创新药物研究与开发。重点领域为抗多药耐药菌药物、抗病毒药物、抗凝血药物、抗肿瘤药物。

2.新药合成新方法、新工艺研究。

dblz:1.Chenghui Shi, Yinyong Zhang, Ting Wang, Wenchao Lu, Shuhua Zhang, Bin Guo, Qian Chen, Cheng Luo, Xianli Zhou,* and Yushe Yang*, Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria，J. Med. Chem. 2019, 62（6）, 2950-2973

2.Deyu K-ong, Tao Xue, Bin Guo, Jianjun Cheng, Shunyin Liu, Jianhai Wei, Zhengyu Lu, Haoran Liu, Guoqing Gong, Tian Lan, Wenhao Hu, and Yushe Yang*，Optimization of P2Y12 Antagonist Ethyl 6?(4-((Benzylsulfonyl) carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties， J. Med. Chem. 2019, 62（6）, 3088-3106

3.Liang Tan, Yunliang Tao, Ting Wang, Feng Zou, Shuhua Zhang, Qunhuan Kou, Ao Niu, Qian Chen, Wenjing Chu, Xiaoyan Chen, Haidong Wang, and Yushe Yang*. Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections. J. Med. Chem. 2017, 60, 2669–2684.

4.Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Wenjing Chu, Wenhao Hu, Yushe Yang*. Design, synthesis, and structure–activity relationship studies of novel fused–heterocycle–linked triazoles with high activity and water solubility. J. Med. Chem. 2014, 56, 3687–3760.

5. Chenyu Ling, Liqiang Fu, Suo Gao, Hui Wang, Yanqin Huang, Xiaoyan Chen and Yushe Yang*. Design, Synthesis, and Structure-Activity Relationship Studies of Novel Thioether Pleuromutilin Derivatives as Potent Antibacterial Agents. J. Med. Chem. 2014, 57, 4772–4795.

6.Tao Xue, Shi Ding, Bin Guo, Yuren Zhou, Peng Sun, Heyao Wang, Wenjing Chu, Guoqing Gong, Yinye Wang, Xiaoyan Chen, and Yushe Yang*. Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel [6,6,5] Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor. J. Med. Chem. 2014, 57, 7770-7791.

7.Bin Guo, Houxing Fan, Qisheng Xin, Wenjing Chu, Hui Wang, Yanqin Huang, Xiaoyan Chen and Yushe Yang*. Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxaziny l-Oxazolidinones Leading to a Promising Antibacterial Agent. J. Med. Chem. 2013, 56, 2642–2650.

8.Qisheng Xin, Houxing Fan, Bin Guo, Huili He, Suo Gao, Hui Wang, Yanqin Huang, Weiliang Zhu, Yushe Yang*. Design, Synthesis and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterials. J. Med. Chem. 2011, 54, 7493–7502.

jyjl:9/1/1983-8/1/1987四川大学，化学学士学位