中国科学院上海药物研究所导师教师师资介绍简介-沈建华

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本站小编 Free考研考试/2021-02-10

xm:沈建华
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:jhshen@simm.ac.cn
grzy:
zjlb:研究员；新药；
zw:中国科学院上海药物研究所研究员、课题组长、博士生导师
txdz:上海市浦东新区张江高科技园区海科路501号
grjj:1998年复旦大学博士毕业。现为中国科学院上海药物研究所课题组长、研究员、博士生导师。从事慢性病（肠炎、肾病、糖尿病等）创新药物的发现研究工作。申请国内外发明专利30多项，已获授权发明专利25项。已在PNAS、JACS、JMC等国际知名学术期刊上发表论文120多篇。
yjfx:1. 基于功能表型或者基于靶标结构的化合物结构优化和成药性研究

2. 一些慢性疾病（如糖尿病、慢性肾病、慢性肠炎、脂肪肝炎和视网膜疾病）的新药发现研究

dblz:1. Fubao Huang, Kai Wang*, Jianhua Shen*. Lipoprotein-associated phospholipase A2: The story continues. Med Res Rev. (2019), 1-56.

2. Qiufeng Liu, Fubao Huang, Xiao-Jing Yuan, Kai Wang, Yi Zou, Jianhua Shen*, and Yechun Xu*. Structure-guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-associated Phospholipase A2. J. Med. Chem. (2017), 60, 10231-10244.

3. Hua Cao, Zhi-Xiang Chen, Kai Wang, Meng-Meng Ning, Qing-An Zou, Ying Feng, Yang-Liang Ye, Ying Leng* & Jian-Hua Shen*. Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect. Sci Rep. (2016), 6: 28676.

4. Qiufeng Liu, Xinde Chen, Wuyan Chen, Xiaojing Yuan, Haixia Su, Jianhua Shen*, and Yechun Xu*. Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors. J. Med. Chem. (2016), 59, 5115-5120.

5. Xinde Chen, Kai Wang,Wenwei Xu, Quanxin Ma, Minli Chen, Lili Du, Mingguang Mo, Yiping Wang*, and Jianhua Shen*. Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema. J. Med. Chem. (2016), 59, 2674-2687.

6. Shan-yao MA, Meng-meng NING, Qing-an ZOU, Ying FENG, Yang-liang YE, Jian-hua SHEN*, Ying LENG*. OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition. Acta Pharmacologica Sinica (2016) ,37:1359–1369.

7. Xinde Chen, Wenwei Xu, Kai Wang, Mingguang Mo, Wei Zhang, Lili Du, Xiaojing Yuan, Yechun Xu, Yiping Wang*, and Jianhua Shen*. Discovery of a novel series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors. J. Med. Chem.(2015),58, 8529-8541.

8. Hongliang Duan, Mengmeng Ning, Qingan Zou, Yangliang Ye, Ying Feng, Lina Zhang, Ying Leng*, and Jianhua Shen*. Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes. J. Med. Chem. (2015),58, 3315-3328.

9. Qingan Zou, Hongliang Duan, Mengmeng Ning, Jia Liu,Ying Feng, Liming Zhang, Junjie Zhu, Ying Leng*, Jianhua Shen*. 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists. Eur J. Med Chem. (2014), 82, 1-15.

10. Hongliang Duan, Mengmeng Ning, Xiaoyan Chen, Qingan Zou, Liming Zhang, Ying Feng, Lina Zhang,Ying Leng*, and Jianhua Shen*. Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists. J. Med. Chem. (2012), 55, 10475-10489.

jyjl:1995-1998复旦大学获博士学位