xm:戴辉雄
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:hxdai@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长，博士生导师
txdz:上海市浦东张江祖冲之路555号
grjj:戴辉雄博士现任中国科学院上海药物研究所研究员、课题组长。2007年在中科院上海有机化学研究所获得博士学位，导师：陆熙炎院士。2007-2009年，美国德州大学从事博士后研究，导师；H. V. Rasika Dias教授；2009-2012年，美国Scripps研究所担任研究助理，导师：余金权教授；2012.7-2016.2中国科学院上海有机化学研究所担任副研究员; 2016.2-至今，中科院上海药物所担任研究员。目前主要致力于开发新型的官能团转化方法，用于天然产物和药物分子的结构修饰，从而发展出高效的先导化合物的优化策略，更好地服务于新药研发。具体研究方向为C-H键和C-C键活化官能团化。在国际学术期刊Nature，J. Am. Chem. Soc, Angew. Chem. Int. Ed.等上已经发表论文40余篇，他引达到了2600余次；申请专利2项。
yjfx:主要从事C-H键和C-C键活化官能团化以及高通量药物合成；研究开发新型的官能团转化方法，用于天然产物和药物分子的结构修饰，从而发展出高效的先导化合物的优化策略，更好地服务于新药研发。
dblz:1.Hanyuan Li, Biao Ma, Qi-Sheng Liu, Mei-Ling Wang, Zhen-Yu Wang, Hui Xu, Ling-Jun Li, Xing Wang, Hui-Xiong Dai*. Transformations of Aryl Ketones via Ligand Promoted C–C Bond Activation. Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie..2.Peng Wu, Tai-Jin Cheng, Hai-Xia Lin, Hui Xu, Hui-Xiong Dai*. Copper-Mediated C-H Thiolation of (Hetero)Arenes Using Weakly Coordinating Directing Group. Tetrahedron Lett. 2020, DOI:10.1016/j.tetlet.2020.152062.3.Ya-Fang Cao, Ling-Jun Li, Min Liu, Hui Xu,* Hui-Xiong Dai*. Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O Methyl S Aryl Thiocarbonates. J. Org. Chem. 2020, 85, 4475-4481.4.Xing Yi, Ya-Fang Cao, Xing Wang, Hui Xu*, Shu-Rong Ban*, Hui-Xiong Dai*. Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature. Tetrahedron Lett. 2020, 61, 151780.5.Min Liu, Ling-Jun Li, Jun Zhang, Hui Xu*, Hui-Xiong Dai*. Palladium-catalyzed meta-CH bond iodination of arenes with I2. Chinese Chemical Letters, 2020, 31, 1301–1304.6.Shang-Zheng Sun, Ming Shang, Hui Xu, Ming-Hong Li, Tai-Jin Cheng, Hui-Xiong Dai *. Copper Mediated C(sp2)–H Amination and Hydroxylation of Phosphinamides. Chem. Common. 2020, 56, 1444-1447.7.Biao Ma, Peng Wu, Xing Wang, Zhengyu Wang, Hai-Xia Lin, and Hui-Xiong Dai*. Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence. Angew. Chem. Int. Ed. 2019, 58, 13335 –13339.8.Xing Wang，Xing Yi，Hui Xu，Hui-Xiong Dai*. Cu-Mediated C-H Thioetherification of Arenes at Room Temperature. Org. Lett. 2019, 21, 5981-5985.9.Shang-Zheng Sun, Hui Xu, Hui-Xiong Dai*. “Copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3. Chinese Chemical Letters, 2019, 30, 969–972.10.Min Liu, Yu-Wen Liu, Hui Xu* and Hui-Xiong Dai*. Palladium-catalyzed Intramolecular C–H Acylation of Indoles with Thioester. Tetrahedron Lett. 2019, 60, 151061.11.Hui Xu, Min Liu, Ling-Jun Li. Ya-Fang Cao, Jin-Quan Yu*, Hui-Xiong Dai*. Palladium-Catalyzed Remote meta-C–H Bond Deuteration of Arenes Using a Pyridine Template. Org. Lett. 2019, 21, 4887-4891.12.Minghong Li, Ming Shang, Hui Xu, Xing Wang, Hui-Xiong Dai*, Jin-Quan Yu*, “Remote Para-C–H Acetoxylation of Electron-Deficient Arenes. Org. Lett., 2019, 21, 540–544.13.Lin-Lin Xu, Xing Wang, Biao Ma, Ming-Xing Yin, Hai-Xia Lin, Hui-Xiong Dai*, Jin-Quan Yu. Copper mediated C–H amination with oximes: en route to primary anilines. Chem. Sci., 2018, 9, 5160-5164.14.Lin-Lin Xu, Hui Xu, Haixia Lin*, Huixiong Dai*, Progress in the Synthesis of Primary Anilines via C—H Bond Functionalization. Chin. J. Org. Chem. 2018, 38, 1940-1948 (in Chinese).15.Wei-Jun Kong, Qian Shao, Ming-Hong Li, Zeng-Le Zhou, Hui Xu, Hui-Xiong Dai*, Jin-Quan Yu*, “Copper-Mediated Diastereoselective C–H Thiolation of Ferrocenes. Organometallics, 2018, 37, 2832–2836.16.Wei-Jun Kong, Xingrong Chen, Mingming Wang, Hui-Xiong Dai*, Jin-Quan Yu*, Rapid Syntheses of Heteroaryl-Substituted Imidazo[1,5 a]indole and Pyrrolo[1,2 c]imidazole via Aerobic C2-H Functionalizations. Org. Lett. 2018, 20, 284-287.17.Ming-Zhu Lu, Xing-Rong Chen, Hui Xu, Hui-Xiong Dai*, Jin-Quan Yu* Ligand-enabled ortho-C–H olefination of phenylacetic amides with unactivated alkenes. Chem. Sci., 2018, 9, 1311-1316.18.Ming Shang, Qian Shao, Shang-Zheng Sun, Yan-Qiao Chen, Hui Xu, Hui-Xiong Dai*, Jin-Quan Yu*. Identification of monodentate oxazoline as a ligand for copper-promoted ortho-C–H hydroxylation and amination.Chem. Sci., 2017, 8, 1469-1473.19.Ming Shang, Ming-Ming Wang, Tyler G. Saint-Denis, Ming-Hong Li, Hui-Xiong Dai*, Jin-Quan Yu*. Copper-Mediated Late-Stage Functionalization of HeterocycleContaining Molecules. Angew. Chem. Int. Ed. 2017, 56, 5317–5321.20.Ming Shang, Shang-Zheng Sun, Hong-Li Wang, Ming-Ming Wang, Hui-Xiong Dai*. Recent Progress on Copper-Mediated Directing-Group-Assisted C(sp2)–H Activation. Synthesis 2016, 48, 4381–4399.21.Wei-Jun Kong, Yue-Jin Liu, Hui Xu, Yan-Qiao Chen, Hui-Xiong Dai*, Jin-Quan Yu*. Pd-Catalyzed α?Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams. J. Am. Chem. Soc. 2016, 138, 2146-2149.22.Jian He, Heng Jiang, Ryosuke Takise, Ru-Yi Zhu, Gang Chen, Hui-Xiong Dai, T. G. Murali Dhar, Jun Shi, Hao Zhang, Peter T. W. Cheng, and Jin-Quan Yu* Ligand-Promoted Borylation of C(sp3)-H Bonds with Palladium(II) Catalysts. Angew.Chem. Int. Ed. 2016, 55, 785–78923.Mingming Wang, Zixiao Wang, Ming Shang, Huixiong Dai*. Transition-Metal-Catalyzed C–H AlkynylationChin. J. Org. Chem. 2015, 35, 570-577 (in Chinese).24.Shang-Zheng Sun, Ming Shang, Hong-Li Wang, Hai-Xia Lin*, Hui-Xiong Dai*, Jin-Quan Yu*. Cu(II)-Mediated C(sp2 )-H Hydroxylation. J. Org. Chem. 2015, 80, 8843?884825.Hui Xu, Ming Shang, Hui-Xiong Dai*, Jin-Quan Yu* “Ligand-Controlled Para-Selective C–H Arylation of Monosubstituted Arenes”. Org. Lett. 2015, 17, 3830?3833.26.Hong-Li Wang, Ming Shang, Shang-Zheng Sun, Zeng-Le Zhou, Brian N. Laforteza, Hui-Xiong Dai*, Jin-Quan Yu*. “Cu(II)-Catalyzed Coupling of Aromatic C–H Bonds with Malonates”. Org. Lett. 2015, 17, 1228-1231.27.Yue-Jin Liu, Hui Xu, Wei-Jun Kong, Ming Shang, Hui-Xiong Dai*, Jin-Quan Yu* “Overcoming the limitations of directed C–H functionalizations of heterocycle.s”. Nature, 2014, 515, 389–393.28.Ming Shang, Shang-Zheng Sun, Hui-Xiong Dai*, Jin-Quan Yu* “Cu(OAc)2-Catalyzed Coupling of Aromatic C–H Bonds with Arylboron Reagents”. Org. Lett. 2014, 16, 5666-5669.29.Ming Shang, Shang-Zheng Sun, Hong-Li Wang, Brian N. Laforteza, Hui-Xiong Dai*, Jin-Quan Yu*. ”Exceedingly Fast Copper(II)-Promoted ortho C-H Trifluoromethylation of Arenes using TMSCF3”. Angew. Chem. Int. Ed. 2014, 53, 10439–10442.30.Ming Shang, Hong-Li Wang, Shang-Zheng Sun, Hui-Xiong Dai*, Jin-Quan Yu* “Cu(II)-Mediated Ortho C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes”. J. Am. Chem. Soc. 2014, 136, 11590–11593.31.Ming Shang, Shang-Zheng Sun, Hui-Xiong Dai*, Jin-Quan Yu*. “Cu(II)-Mediated C–H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles”. J. Am. Chem. Soc. 2014, 136, 3354–3357.32.Ming Shang, Shao-Hang Zeng, Shang-Zheng Sun, Hui-Xiong Dai*, Jin-Quan Yu*. “Ru(II)-Catalyzed ortho-C–H Amination of Arenes and Heteroarenes at Room Temperature”. Org. Lett. 2013, 15, 5286-5289.33.Hui-Xiong Dai, Gang Li, Xing-Guo Zhang, Antonia F. Stepan, Jin-Quan Yu*. ” Pd(II)-Catalyzed ortho- or meta-C–H Olefination of Phenol Derivatives”. J. Am. Chem. Soc. 2013, 135, 7567–7571.34.Hui-Xiong Dai, Jin-Quan Yu*. “Pd-Catalyzed Oxidative ortho-C–H Borylation of Arenes”. J. Am. Chem.Soc. 2012, 134, 134–137.35.Xing-Guo Zhang, Hui-Xiong Dai, Masayuki Wasa, Jin-Quan Yu*. “Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups”. J. Am. Chem. Soc. 2012, 134, 11948–11951.36.Hui-Xiong Dai, Antonia F. Stepan, Mark S. Plummer, Yang-Hui Zhang, Jin-Quan Yu*. “Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery”. J. Am. Chem. Soc. 2011, 133, 7222–7228.37.Xisheng Wang, Yi Lu, Hui-Xiong Dai, Jin-Quan Yu*. “Pd(II)-Catalyzed Hydroxyl-Directed C?H Activation/C?O Cyclization: Expedient Construction of Dihydrobenzofurans”. J. Am. Chem. Soc. 2010, 132, 12203-12205.38.Huixiong Dai, xiyan Lu*“Palladium(II)/2,2\'-bipyridine-catalyzed addition of arylboronic acids to N-tosyl-arylaldimines”Tetrahedron Lett. 2009, 50, 3478.39.Mauro Fianchini, Huixiong Dai, H. V. Rasika Dias*, “Organometallic Wheels Based on Coinage Metal Ions and Norbornene: Syntheses and Structural Characterization of [M(norbornene)3] [SbF6] (M = Au, Ag, Cu)” Chem.Common. 2009, 42, 6373.40.Huixiong Dai, Miao Yang and xiyan Lu* “Palladium(II)-Catalyzed One-pot Enantioselective Synthesis of Arylglycine Derivatives from Ethyl Glyoxylate p-Toluenesulfonyl Isocyanate and Arylboronic Acids,Adv. Synth. Cat. 2008, 350, 249.41.Huixiong Dai, xiyan Lu*,“Diastereoselective Synthesis of Arylglycine Derivatives by Cationic Palladium(II)-Catalyzed Addition of Arylboronic Acids to N-tert-Butanesulfinyl Imino Esters”Org. Lett. 2007, 9, 3077.
jyjl:中科院上海有机化学研究所，有机化学，博士
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