xm:徐石林
xb:男
zc:研究员
xl:博士
dh:-2115
cz:
dzyj:slxu@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海市浦东新区张江高科技园区海科路501号　201203
grjj:徐石林，中国科学院上海药物研究所研究员，课题组长。2014年于中国科学院广州生物医药与健康研究院获得博士学位，随后进入美国密歇根大学安娜堡分校进行博士后研究，2019年9月加入上海药物研究所，担任课题组长。主要从事新药分子设计、合成与开发工作，围绕克服肿瘤耐药这一重大临床需求，取得了一系列重要成果，相关工作在Angew. Chem. Int. Ed.; J. Med. Chem等国际学术期刊发表文章10 篇，同时申请了多项中国和国际发明专利，部分专利已获授权。作为Menin抑制剂项目的主要贡献者，设计了该靶点的世界首个共价抑制剂，推动了该项目成功转让给国际著名制药公司，使合作团队获得了高额转让费。

yjfx:1.克服肿瘤耐药的小分子药物开发,
2.靶向肿瘤免疫和肿瘤代谢的新药小分子开发及抗肿瘤机制研究
dblz:1. Xu, Shilin#; Aguilar, Angelo#; Huang, Liyue#; Xu, Tianfeng; Zheng, Ke; McEachern, Donna; Przybranowski, Sally; Foster, Caroline; Zawacki, Kaitlin; Liu, Zhaomin; Chinnaswamy, Krishnapriya; Stuckey, Jeanne; Wang, Shaomeng*, Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity. Journal of Medicinal Chemistry 2020, 63 (9), 4997-5010. (# Co-first author)

2. Chang, Yu; Xu, Shilin; Ding, Ke*, Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases. Journal of Medicinal Chemistry 2019, 62 (20), 8951-8952.

3. Xu, Shilin#; Aguilar, Angelo#; Xu, Tianfeng#; Zheng, Ke#; Huang, Liyue; Stuckey, Jeanne; Chinnaswamy, Krishnapriya; Bernard, Denzil; Fernández‐Salas, Ester; Liu, Liu; Wang, Mi; McEachern, Donna; Przybranowski, Sally; Foster, Caroline; Wang, Shaomeng*, Design of the first‐in‐class, highly potent irreversible inhibitor targeting the menin‐MLL protein–protein interaction. Angewandte Chemie International Edition 2018, 57 (6), 1601-1605. (# Co-first author)

4. Aguilar, Angelo#; Zheng, Ke#; Xu, Tianfeng#; Xu, Shilin#; Huang, Liyue#; Fernandez-Salas, Ester; Liu, Liu; Bernard, Denzil; Harvey, Kaitlin P.; Foster, Caroline; McEachern, Donna; Stuckey, Jeanne; Chinnaswamy, Krishnapriya; Delproposto, James; Kampf, Jeff W.; Wang, Shaomeng*, Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction. Journal of medicinal chemistry 2019, 62 (13), 6015-6034. (# Co-first author)

5. Xu, Shilin#; Mao, Liufeng#; Ding, Ping#; Zhuang, Xiaoxi; Zhou, Yang; Yu, Lei; Liu, Yingxue; Nie, Tao; Xu, Tingting; Xu, Yong; Liu, Jinsong; Smaill, Jeff; Ren, Xiaomei*; Wu, Donghai*; Ding, Ke*, 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose. Bioorganic & Medicinal Chemistry 2015, 23 (13), 3751-3760. (# Co-first author)

6. Xu, Shilin; Xu, Tianfeng; Zhang, Lianwen; Zhang, Zhang; Luo, Jinfeng; Liu, Yingxue; Lu, Xiaoyun; Tu, Zhengchao; Ren, Xiaomei; Ding, Ke*, Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor Inhibitors with Improved Pharmacokinetic Properties. Journal of medicinal chemistry 2013, 56 (21), 8803-8813.

7. Xu, Shilin; Zhuang, Xiaoxi; Pan, Xiaofen; Zhang, Zhang; Duan, Lei; Liu, Yingxue; Zhang, Lianwen; Ren, Xiaomei*; Ding, Ke*, 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as Orally Bioavailable Transcriptional Function Suppressors of Estrogen-Related Receptor α. Journal of medicinal chemistry 2013, 56 (11), 4631-4640.

8. Xu, Shilin; Zhang, Lianwen; Chang, Shaohua; Luo, Jinfeng; Lu, Xiaoyun; Tu, Zhengchao; Liu, Yingxue; zhang, Zhang; Xu, Yong; Ren, Xiaomei; Ding, Ke*, Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790→ methionine790 mutant. MedChemComm 2012, 3 (9), 1155-1159.

9. Xu, Tianfeng#; Zhang, Lianwen#; Xu, Shilin; Yang, Chao-Yie; Luo, Jinfeng; Ding, Fang; Lu, Xiaoyun; Liu, Yingxue; Tu, Zhengchao; Li, Shiliang; Pei, Duanqing; Cai, Qian; Li, Honglin; Ren, Xiaomei; Wang, Shaomeng; Ding, Ke*, Pyrimido[4,5-d]pyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants. Angewandte Chemie International Edition 2013, 52 (32), 8387-8390.

10. Chang, Shaohua#; Zhang, Lianwen#; Xu, Shilin; Luo, Jinfeng; Lu, Xiaoyun; Zhang, Zhang; Xu, Tianfeng; Liu, Yingxue; Tu, Zhengchao; Xu, Yong; Ren, Xiaomei; Geng, Meiyu; Ding, Jian; Pei, Duanqing; Ding, Ke*, Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant. Journal of medicinal chemistry 2012, 55 (6), 2711-2723.

代表专利：

1. 丁克，徐石林，徐田锋，张连文，丁芳，涂正超，陆小云，丁健，耿美玉，嘧啶并杂环类化合物及其药用组合物和应用（中国授权专利号：0X）

2. 丁克，徐石林，庄晓曦，潘小芬，张章，段磊，陆小云，用作雌激素相关受体调节剂的化合物及其应用（中国授权专利号：20**）

3. 丁克，徐石林，常少华，张连文，涂正超，许永，陆小云，嘧啶并二氮杂卓类化合物及其药用组合物和应用（中国授权专利号：7X）

4. 丁克，常少华，徐石林，张连文，涂正超，丁健，耿美玉，陈奕，嘧啶并嘧啶酮类化合物及其药用组合物和应用（中国授权专利号：99）

5. 丁克，徐田锋，常少华，张连文，罗金凤，徐石林，肖宜平，涂正超，嘧啶并三环或嘧啶并四环类化合物及其药用组合物和应用（中国，授权专利号：93）

6. Shaomeng Wang, Shilin Xu, Angelo Aguilar, Liyue Huang, Jeanne Stuckey, PIPERIDINE COMPOUNDS AS COVALENT MENIN INHIBITORS (PCT专利申请号：PCT/US 2019/024729)

7. Shaomeng Wang, Shilin Xu, Angelo Aguilar, Liyue Huang, Tianfeng Xu, CYCLOPENTYL CARBAMATES AS MENIN INHIBITORS (美国专利申请号：62/740,561)

8. Shaomeng Wang, Shilin Xu, Angelo Aguilar, Liyue Huang, SMALL MOLECULE MENIN INHIBITORS (美国专利申请号：62/740,567)

9. Shaomeng Wang, Angelo Aguilar, Shilin Xu, Liyue Huang, Jeanne Stuckey, Tianfeng Xu, PIPERIDINES AS COVALENT MENIN INHIBITORS (PCT专利申请号：PCT/US2018/025417)

10. Shaomeng Wang, Angelo Aguilar, Ke Zheng, Shilin Xu, Tianfeng Xu, Denzil Bernard, PIPERIDINES AS MENIN INHIBITORS (PCT专利申请号：PCT/US2017/030577)

jyjl:2005.9 -- 2009.7南昌大学，理学学士