删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

中国科学院上海药物研究所导师教师师资介绍简介-张仰明

本站小编 Free考研考试/2021-02-10

xm:张仰明
xb:男
zc:研究员
xl:博士
dh:**-186
cz:
dzyj:ymzhang@simm.ac.cn
grzy:
zjlb:
zw:
txdz:上海浦东张江郭守敬路189号
grjj:  张仰明,男,博士,中国科学院上海药物研究所研究员,主要从事新药发现研究及候选新药的临床前开发工作,参与及负责了多个创新药物的临床前原料药药学研究和后期的临床申报工作,其中两个新药品种已获得临床批件,并进入临床研究。  

教育经历:

  1994.9-1998.6,大学本科,上海师范大学

  1998.9-2001.6,硕士研究生,华东师范大学

  2006.9-2009.6,博士研究生,华东师范大学

工作经历:

  2001.7-2002.6,上海药物研究所,国家新药筛选中心

  2002.7-2003.6,希比希(上海)贸易有限公司

  2003.7-至今,上海药物研究所,国家新药筛选中心


yjfx:1. 新药发现研究,基于天然产物关键结构骨架及某些优势结构单元,通过合成方法学研究,开展先导化合物的发现研究;
2. 候选新药的临床前开发,以合成工艺研究为切入点,协调推进候选新药的质控、制剂、药效、毒理及药代等项目,在此基础上开展临床申报工作。


dblz:1.Chaojun Gong, Anhui Gao, Yangming Zhang, Mingbo Su, Fei Chen, Li Sheng,YuBo Zhou, JingYa Li, Jia Li, FaJun Nan. Design, Synthesis and Biological Evaluation of Bisthiazole-based Trifluoromethyl Ketone Derivatives as Potent HDAC Inhibitors with Improved Cellular Efficacy, Eur J Med Chem. 2016, 112, 81-90.

2.Yang Li, Yajuan Wang, Haijun Chen; Liping Shi, Xiankun Tong,Yangming Zhang, Guifeng Wang, Wenlong Wang, Chunlan Feng, Peilan He, Yibing Xu, Mengji Lu, Wei Tang, Fajun Nan, Jianping Zuo. Effect of a Hepatitis B Virus Hnhibitor, NZ-4, on Capsid Formation, Antivil Res. 2016, 125, 25-33.

3.*Pingzheng Zhou, *Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan, and Zhaobing Gao. P-Retigabine: an N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, Mol Pharmacol, 2015, 87, 31,i Ch

4.Fei Chen, Hui Chai, Mingbo Su, Yangming Zhang, Jia Li, Xin Xie, Fajun Nan. Potent and Orally Efficacious Bisthiazole-based Histone Deacetylase Inhibitors, ACS Med Chem Lett. 2014, 5(6), 628-33.

5.Li Yang, Liping Shi, Haijun Chen, Xiankun Tong, Guifeng Wang, Yangming Zhang, Wenlong Wang, Chunlan Feng, Peilan He, Fenghua Zhu, Youhua Hao, Baoju Wang, Dongliang Yang, Wei Tang, Fajun Nan, Jianping Zuo. Isothiafludine, a Novel Non-nucleoside Compound, Inhibits Hepatitis B Virus Replication through Blocking Pregenomic RNA Encapsidation, Acta Pharmacol Sin, 2014, 35, 410rmacolMin Gu, Yangming Zhang, Wei Luo, Wei Lu, Fajun Nan. A Facile Semisythesis of 2\', 7-Bisacetyltaxol from 10-DAB. Chem. Nat. Compd., 2012, 48, 702-703.

6.*Mei Zhang, *Yangming Zhang, Wei Lu, Fajun Nan. Synthesis and Revision of Stereochemistry of Rubescensin S, Org Biomol Chem, 2011, 9, 4436-4439.

7.Xiaoying Li, Yangming Zhang, Jie Tang, Fan Yang, Fajun Nan. One-pot Synthesis of 2,4-Diamino-substituted Thieno[3,2-d]pyrimidines, Chin J Chem, 2010, 28, 1437-1440.

8.Yangming Zhang, Yu Ding, Wei Tang, Wei Luo, Min Gu, Wei Lu, Jie Tang, Fajun Nan. Synthesis and Biological Evaluation of Immunosuppressive Agent DZ2002 and its Steroisomers, Bioorg Med Chem, 2008, 16, 9212-9216.

9.Yangming Zhang, Min Gu, Hui Ma, Jie Tang, Wei Lv, Fajun Nan. An Efficient Synthesis of 2-Chloropyrimidines via Pd-mediated Catalytic Regioselective Dechlorination in the Presence of NaHCO3, Chin J Chem, 2008, 26, 962-964.

10.Qiaojie Xiong, Haiyan Sun, Yangming Zhang, Fajun Nan, Min Li. Combinatorial Augmentation of Voltage-gated KCNQ Potassium Channels by Chemical Openers, Proc Natl Acad Sci USA, 2008, 105, 3128-3133.

  

  


jyjl:
gzjl:1.发表论文共篇,其中被EI/SCI/ISTP/SSCI检索14篇;

2.申请专利15项;

3.作为项目负责人承担项目共5项,其中国家级1项,部(省)级4项


ktxm:1.抗结肠癌候选新药GCJ490-A的临床前开发(CASIMM),中科院创新研究院,2016.8-2018.7

2.五环三萜类PS1-BACE1相互作用抑制剂的设计合成及其功能研究(**),国家自然科学基金面上项目,2016.1-2019.12

3.抗癫痫候选新药HN37的临床前开发(**),上海市科技专项重点项目,2016.7-2019.6

4.抗多发性骨髓瘤候选新药必噻司他(倍赛诺他)的临床前研究(**),上海市科技专项重点项目,2014.7-2017.9


ryhj:2013年赛诺菲—中科院上海生命科学研究院优秀青年人才奖


xpwj:http://sourcedb.simm.cas.cn/zw/gb2020/dsh/202009/P.jpg
kycg:
shrz:
相关话题/中国科学院 上海药物研究所