xm:李铁海
xb:男
zc:研究员
xl:博士
dh:-4091
cz:
dzyj:tiehaili@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海市浦东新区张江高科技园区海科路501号
grjj:李铁海，2012年于南开大学药学院获得化学生物学博士学位，随后在美国佐治亚州立大学化学系和美国乔治亚大学复杂糖研究中心进行博士后研究，2019年9月加入中国科学院上海药物研究所任研究员，课题组长。目前主要从事于发展高效的合成方法制备具有生理活性的复杂糖及糖缀合物，用于药物先导筛选，诊断试剂开发和糖类药物基础理论的创新研究，其相关工作已经发表在Nature Chemistry, Nature Communications, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Eur. J. 等国际学术期刊上。

yjfx:糖及糖缀合物的高效合成和功能研究

dblz:1.Tiehai Li, Margreet A. Wolfert, Na Wei, Ruth Huizinga, Bart C. Jacobs, Geert-Jan Boons*. Chemoenzymatic synthesis of Campylobacter jejuni lipo-oligosaccharide core domains to examine Guillain-Barré syndrome serum antibody specificities.J. Am. Chem. Soc.2020, 142, 19611–19621.

2.Tiehai Li#, Lin Liu#, Na Wei, Jeong-Yeh Yang, Digantkumar G. Chapla, Kelley W. Moremen, Geert-Jan Boons*. An automated platform for the enzyme-mediated assembly of complex oligosaccharides.Nat. Chem. 2019, 11, 229–236.

3.Tiehai Li#, Min Huang#, Lin Liu, Shuo Wang, Kelley W. Moremen, Geert-Jan Boons*. Divergent chemoenzymatic synthesis of asymmetrical core-fucosylated and core-unmodified N-glycans.Chem. Eur. J. 2016, 22, 18742–18746.

4. Baolin Wu#, Na Wei#, Vireak Thon, Mohui Wei, Zaikuan Yu, Yongmei Xu, Xi Chen, Jian Liu, Peng George Wang*,Tiehai Li*. Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide.Org. Biomol. Chem. 2015, 13, 5098–5101.

5. Wenjing Shang#, Zhongying Xiao#, Zaikuang Yu#, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang*,Tiehai Li*. Chemical synthesis of outer core oligosaccharide of E. coli R3 and immunological evaluation.Org. Biomol. Chem. 2015, 13, 4321–4330.

6.Tiehai Li#, Hui Ye#, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, Peng Wang*. Total synthesis of anticoagulant pentasaccharide Fondaparinux.ChemMedChem, 2014, 9, 1071–1080.

7.Tiehai Li#, Liuqing Wen#, Adriel Williams, Baolin Wu, Lei Li, Jingyao Qu, Jeffrey Meisner, Zhongying Xiao, Junqiang Fang, Peng George Wang*. Chemoenzymatic synthesis of ADP-D-glycero-β-D-manno-heptose and study of the substrate specificity of HldE. Bioorg.Med. Chem. 2014, 22, 1139–1147.

8. Ivan A. Gagarinov,Tiehai Li,Na Wei, Javier Sastre Torano, Robert P. de Vries, Margreet A. Wolfert, Geert-Jan Boons*. Protecting-group-controlled enzymatic glycosylation of oligo-N-acetyllactosamine derivatives.Angew. Chem. Int. Ed.2019, 58, 10547–10552.

9. Sharad Purohit, Tiehai Li, Wanyi Guan, Xuezheng Song, Jing Song, Yanna Tian, Lei Li, Ashok Sharma, Boying Dun, David Mysona, Sharad Ghamande, Bunja Rungruang, Richard D. Cummings, Peng George Wang, Jin-Xiong She*. Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins.Nat. Commun. 2018, 9, 258.

10. Ivan A. Gagarinov,Tiehai Li, Javier Sastre Torano, Tomislav Caval, Apoorva D. Srivastava, John A. W. Kruijtzer, Albert J. R. Heck, Geert-Jan Boons*. Chemoenzymatic approach for the preparation of asymmetric bi-, tri-, and tetra-antennary N-glycans from a common precursor.J. Am. Chem. Soc. 2017, 139, 1011–1018.