中国科学院上海药物研究所导师教师师资介绍简介-沈敬山

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xm:沈敬山
xb:男
zc:研究员
xl:博士
dh:-2415
cz:
dzyj:shenjingshan@simm.ac.cn
grzy:
zjlb:研究员
zw:中国科学院上海药物所研究员、博士生导师、课题组长
txdz:上海市浦东新区张江高科技园区海科路501号
grjj:　　沈敬山博士于1998年获得中国科学院上海药物研究所博士学位后留所工作至今。现为中科院上海药物研究所研究员、硕士研究生和博士研究生导师。沈敬山博士是中国科学院特聘研究员和享受国务院特殊津贴专家。

　　工作领域：药物研究；基于源头控制的绿色可持续性有机合成路线设计、工艺研究和产业化应用。

yjfx:1. 中枢神经系统药物；抗病毒药物。

2. 基于“源头控制”策略的绿色可持续性有机合成路线设计、工艺研究和产业化应用。

dblz:1) Yang He1, Rongjuan Pei1, Zhijian Xu1, Zhen Chen, Shuqi Xiao, Han Xia, Jin Xiong, Weiliang Zhu*, Bo Zhang*, Jingshan Shen*, Mycophenolate Mofetil Is Active Against SARS-CoV-2 in Vero E6 Cells. Preprint 2020, .

2) Bingqing Xia1, Xurui Shen1, Yang He1, Xiaoyan Pan1, Yi Wang, Feipu Yang, Sui Fang, Yan Wu, Xiaoli Zuo, Zhuqing Xie, Xiangrui Jiang, Hao Chi, Qian Meng, Hu Zhou, Yubo Zhou, Xi Cheng, Tong Chen, Xiaoming Xin, Hualiang Jiang, Gengfu Xiao, Qiang Zhao, Lei-Ke Zhang*, Jingshan Shen*, Jia Li*, Zhaobing Gao*. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target. bioRxiv 2020.06.27.174953; doi: https://doi.org/10.1101/2020.06.27.174953.

3) Synthesis of CBD and Its Derivatives Bearing Various C4′-Side Chains with a Late-Stage Diversification Method. J. Org. Chem. 2020, 85, 4, 2704-2715

4) Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products. Sci. China Life Sci. 2019, 62, 1-36

5) Pharmacokinetic-driven optimization of 4(3H)-pyrimidiones as phosphodiesterase Type 5 inhibitiors leading to TPN171, a clinical candidate for the treatment of pulmonary arterial hypertension. J. Med. Chem. 2019, 62, 4979?4990

6) Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)?ones to Quinolin-2(1H)?ones Using Transition-Metal-Activated Persulfate Salts. J. Org. Chem. 2019, 84, 8702?8709

7) Industy-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole. Org. Process Res. Dev. 2019, 23, 852?857

8) multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect. Eur. J. Med. Chem. 2018, 145, 74–85

9) Development of a Robust Process for the Preparation of 4 Methylenepiperidine. Org. Process Res. Dev. 2018, 22, 91–96

10) Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase. Current Drug Targets, 2016, 17, 1560-1576

jyjl:09/01/1995 — 07/01/1998中国科学院上海药物研究所攻读药物化学博士