xm:杨春皓
xb:男
zc:研究员
xl:博士
dh:+86-
cz:
dzyj:chyang@simm.ac.cn
grzy:
zjlb:研究员；新药；
zw:研究组长，博士生导师
txdz:上海市浦东新区祖冲之路555号
grjj: 杨春皓现为上海药物研究所研究员、博士生导师、课题组长。作为课题负责人目前承担着多项国家项目，包括“十三五”重大专项子课题、国家自然基金及中国科学院战略先导科技专项A子课题等，共发表同行评审文章九十多篇，申请国内国际专利二十多项，2017年入选中国科学院“特聘骨干人才”。

yjfx:新型抗肿瘤药物、骨相关疾病药物的研发；生物活性为导向的杂环方法学研究
dblz:近五年代表性论著

1. Hao-Yue Xiang , Yan-Hong Chen, Yi Wang, Xi Zhang, Jian Ding, Ling-Hua Meng* and Chun-Hao Yang*. Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives. Bioorg. Med. Chem. Lett. 2020, DOI : 10.1016/j.bmcl.2020.127194

2. Fangran Liu, Xiaofei Zhang, Qun Qian *, Chunhao Yang*. A Concise and Efficient Approach to 2,6-disubstituted-4-Fluoro-pyrimidines from α-CF3 Aryl Ketones. Synthesis. 2020; 52(02): 273-280.

3. Yingyuan Peng, Qian He, Xiaofei Zhang* and Chunhao Yang*. Pd-catalyzed Intramolecular C–H Activation and C–S Formation to Synthesize Pyrazolo[5, 1-b]benzothiazoles without an Additional Oxidant. Org. Chem. Front. 2019, 6, 3234-3237.

4.Min Jiang, Lei Peng, Kai Yang, Tianqi Wang, Xueming Yan, Tao Jiang, Jianrong Xu, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu*, Lianfu Deng*, Chunhao Yang* Development of Small Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL) - Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization. J. Med. Chem., 2019, 62, 5370-5381.

5. Tianzi Dai Qunyi Li, Xiaofei Zhang*, and Chunhao Yang.* Substituent-Oriented Synthesis of Substituted Pyrazoles/ Chromeno[3,2-c]Pyrazoles via Sequential Reactions of Chromones/3-chlorochromones and Tosylhydrazones. J. Org. Chem. 2019, 84 (9), 5913–5921.

6. Xiaofeng Peng, Xiaofei Zhang, Shunyao Li, Yunfu Lu, Lefu Lan * and Chunhao Yang.* Silver-mediated Synthesis of Novel 3-CF3/CN/Phosphonate-substituted Pyrazoles as Pyrrolomycin Analogues from 3-Formylchromones and Diazo Compounds. Org. Chem. Front. 2019, 6, 1775 – 1779.

7. Min Jiang , Tianqi Wang, Xueming Yan, Zhuochao Liu, Yufei Yan, Kai Yang, Jin Qi, Hanbing Zhou, Niandong Qian, Qi Zhou, Bo Chen, Xing Xu*, Xiaobing Xi*, Chunhao Yang*, Lianfu Deng. A novel rhein derivative modulates bone formation and resorption and ameliorates oestrogen-dependent bone loss. J. Bone Miner. Res. 2019, 34(2), 361-374.

8. Bo Jiang, Xiaofei Zhang and Chunhao Yang*. Palladium-catalyzed direct approach to α-CF3 aryl ketones from arylboronic acids. Org. Chem. Front., 2018, 5, 1724-1727.

9. Xuxing Chen, Xiajuan Huan, Qiufeng Liu,YuqinWang, Qian He, Cun Tan, Yi Chen, Jian Ding, Yechun Xu,* Zehong Miao,* and Chunhao Yang*. Design and Synthesis of 2-(4,5,6,7-Tetrahydrothienopyridin-2-yl)-benzoimidazole Carboxamides as Novel Orally Efficacious Poly(ADP-ribose)polymerase (PARP) Inhibitors. Eur. J. Med. Chem. 2018, 145, 389-403.

10. Jing Li, Xiaofei Zhang, Haoyue Xiang, Linjiang Tong, Fang Feng, Hua Xie, Jian Ding, and Chunhao Yang.* C-H Trifluoromethylation of 2-Substitued/Unsubstituted-amino-naphthoquinones at Room Temperature with Bench-stable (CF3SO2)2Zn: Synthesis and Antiproliferative Evaluation. J. Org. Chem. 2017, 82, 6795-6800.

11. Bin Zhang, Xiaofei Zhang, Jian Hao,* and Chunhao Yang.* Direct Approach to N-Substituted-2-Fluoroindoles by Sequential Construction of C-N Bonds from gem-Difluorostyrenes. Org. Lett., 2017, 19 (7), 1780–1783.

12. Jin-Xue He, Meng Wang, Xia-Juan Huan, Chuan-Huizi Chen, Shan-Shan Song, Ying-Qing Wang, Xue-Mei Liao, Cun Tan, Qian He, Lin-Jiang Tong, Yu-Ting Wang, Xiao-Hua Li, Yi Su, Yan-Yan Shen, Yi-Ming Sun, Xin-Ying Yang, Yi Chen, Zhi-Wei Gao, Xiao-Yan Chen, Bing Xiong, Xiu-Lian Lu, Jian Ding, Chun-Hao Yang,* Ze-Hong Miao.* Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution. Oncotarget. 2017 ;8(3):4156-4168.

13. Xing Xu, Xueyu Qi, Yufei Yan, Jin Qi, Niandong Qian, Lei Guo, Changwei Li, Fei Wang, Ping Huang, Hanbing Zhou, Min Jiang, * Chunhao Yang* and Lianfu Deng. Synthesis and biological evaluation of rhein amides as inhibitors of osteoclast differentiation and bone resorption. Eur. J. Med. Chem. 2016, 123, 769-776.

14. Xia Liu, Zhijian Xu, Chuanwei Hou, Meng Wang, Xinhuan Chen, Qinghui Lin, Rui Song, Meng Lou, Lijun Zhu, Yunqing Qiu, Zhi Chen, Chunhao Yang*, Weiliang Zhu*, Jimin Shao.* Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. Biochemical Pharmacology, 2016, 103, 118-128.

15. Xueyu Qi, Haoyue Xiang, and Chunhao Yang * Synthesis of functionalized chromeno[2,3-b]pyrrol-4(1H)-ones by silver-catalyzed cascade reactions of chromones/thiochromones and isocyanoacetates. Org. Lett. 2015, 17, 5590-5593.

16. Min Jiang, Haoyue Xiang, Fangxia Zhu, Xing Xu, Lianfu Deng, * and Chunhao Yang.* Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives. Org. Biomol. Chem., 2015, 13, 10122-10126. (Highlighted by Synfacts, 2015, 11(12), 1250)

17. Xiaofei Zhang, and Chunhao Yang* Alkylations of Aryl Boronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction. Adv. Synth. Catal. 2015, 357, 2721-2727.

18. Min Jiang, Fangxia Zhu, Haoyue Xiang, Xing Xu, Lianfu Deng,* and Chunhao Yang.* An Efficient and Practical Approach to Trifluoromethylthiolation of α-Haloketones/α-Haloarylmethanes. Org. Biomol. Chem., 2015, 13, 6935 – 6939.

19. Jun-Mei Yi，Xiao-Fei Zhang，Xia-Juan Huan，Shan-Shan Song, Wei Wang, Qian-Ting Tian, Yi-Ming Sun, Yi Chen, Jian Ding, Ying-Qing Wang,* Chun-Hao Yang,* Ze-Hong Miao.* Dual Targeting of Microtubule and Topoisomerase II by α-Carboline Derivative YCH337 for Tumor Proliferation and Growth Inhibition. Oncotarget, 2015, 6,11, 8960-8973.

jyjl:09/01/1988-06/30/1992苏州大学化学系，本科