xm:周宇
xb:男
zc:研究员
xl:博士
dh:-5418
cz:
dzyj:zhouyu@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长、博士生导师
txdz:上海市浦东新区祖冲之路555号
grjj:现任中国科学院上海药物所研究员、课题组长、博士生导师。2008年7月获得理学博士学位，长期以“新药研究”为主线，探索和发展高效的有机合成新方法，针对性构建类药性杂环化合物库，并重点针对老年性疾病、恶性肿瘤等重大疾病开展创新药物研究，目前作为核心研究者主持开发的一类抗AD候选药物和一类抗良性前列腺增生症候选药物均已获批进入I期临床研究。并在Chem Rev、J Med Chem和ACS Catal等国内外学术期刊上共发表论文90余篇，申请发明专利20余项，转让2项，并先后获得施维雅青年药物化学奖、SANOFI-SIBS优秀人才奖等资助，并入选上海药物所新星计划、中科院青年创新促进会第一届会员及第一届优秀会员等。

yjfx:1. 围绕神经、精神系统等脑部疾病的创新药物研究

2. 基于肿瘤新靶标的创新药物研究

3. 基于过渡金属催化的高效合成技术开发、构建类药性杂环化合物库

dblz:1.Qiaolan Yang, Chenglin Wu, Jianhui Zhou, Guoxue He, Hong Liu* and Yu Zhou*. Highly selective C–H bond activation of N-arylbenzimidamide and divergent couplings with diazophosphonate compounds: a catalyst-controlled selective synthetic strategy for 3-phosphorylindoles and 4-phosphorylisoquinolines. Org. Chem. Front. 2019, 6, 393-398.

2.Chenglin Wu, Jianhui Zhou, Guoxue He, Huihui Li, Qiaolan Yang, Run Wang, Yu Zhou* and Hong Liu*. Ruthenium(II)-Catalyzed Selective C-H Bond Activation of Imidamides and Coupling with Sulfoxonium Ylides: An Efficient Approach for the Synthesis of Highly Functional 3-Ketoindoles. Org. Chem. Front. 2019, 6, 1183-1188.

3.Jianhui Zhou, Jian Li, Yazhou Li, Chenglin Wu, Guoxue He, Qiaolan Yang, Yu Zhou* and Hong Liu*. Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones. Org. Lett. 2018, 20, 7645-7649.

4.Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yazhou Li, Yu Zhou* and Hong Liu*. Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[ de]chromenes. Org. Lett. 2018, 20, 1720-1724.

5.Chaofan Zhou, Feifei Fang, Yilang Cheng, Yazhou Li, Hong Liu* and Yu Zhou*. Rh(III)‐Catalyzed C‐H Activation of Benzoylacetonitriles and Cyclization with Sulfoxonium Ylides to Naphthols. Adv. Synth. Catal. 2018, 360 (13), 2546-2551.

6.Yazhou Li, Jianhui Zhou, Feifei Fang, Bin Xu, Hong Liu* and Yu Zhou*. Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2 H-Isoindoles. J. Org. Chem. 2018, 83, 11736-11746.

7.Xiaowei Wu, Bao Wang, Shengbin Zhou, Yu Zhou* and Hong Liu.* Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl alcohols via C-H Bond Activation. ACS Catal. 2017, 7, 2494–2499.

8.Wenjing Xia, Hong Yao, Dan Liu, Linxiang Zhao, Yu Zhou* and Hong Liu*. Enantioselective N-Heterocyclic Carbene-Catalyzed [3+3] Annulation of α,β-Unsaturated Esters with Methyl Ketoimine. Adv. Synth. Catal. 2016, 358, 1864-1869.

9.Yu Zhou, Jiang Wang, Zhanni Gu, Shuni Wang,Wei Zhu, Jose Acena,Vadim Soloshonok, Kunisuke Izawa, Hong Liu*. Next Generation of Fluorine-containing Pharmaceuticals Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies; New Structural Trends and Therapeutic Areas. Chem. Rev. 2016, 116, 422–518.

10.Yu Zhou, Jun Liu, Mingyue Zheng, Shuli Zheng, Chunyi Jiang, Xiaomei Zhou, Dong Zhang, Jihui Zhao, Deju Ye, Mingfang Zheng, Hualiang Jiang, Dongxiang Liu, Jian Cheng and Hong Liu. Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase. Acta Pharmaceutica Sinica B. 2016, 6, 32–45.

jyjl:1999.09 — 2003.07沈阳药科大学 制药工程 学士