xm:黄蔚
xb:男
zc:研究员
xl:博士
dh:+86--2517
cz:
dzyj:huangwei@simm.ac.cn
grzy:
zjlb:研究员
zw:中科院上海药物研究所研究组长；博士生导师
txdz:上海市浦东新区张江高科技园区海科路501号
grjj: 2005年在中国科学院上海药物研究所获得有机化学博士学位。2005-2006年在美国犹他大学从事博士后研究,2006-2010年在美国马里兰大学任研究助理,2010-2012年在美国马里兰大学任助理教授。2012年受聘于上海药物研究所，担任课题组长。

长期从事糖类药物研究，在糖化学和糖生物学交叉领域，发展新的糖类药物设计技术，在糖基化优化的单克隆抗体药物、基于糖链定点的抗体药物偶联物（ADC）药物、抗耐药菌的糖肽抗生素、糖苷类小分子抗肿瘤药物、靶向受体糖基化干预策略等项目上，取得了积极的成果，相应的药物候选分子在进行系统的临床前评价。研究成果在Nat.Chem. Biol., Nat. Protoco., Angew. Chem. Int. Ed., J. Am. Chem. Soc., J. Med. Chem.等专业期刊发表文章70余篇，近5年引用数大于2500次，H-index为28。

yjfx:1．单克隆抗体药物的糖基化改造与抗体药物偶联物（ADC）的研发
2．复杂天然产物糖修饰策略与新型糖结构药物研发
3．药物受体糖基化结构与功能及靶向糖基化干预策略
4．细胞表面糖链标记、成像与膜受体糖链功能研究
dblz:1.Tang, F.; Zhou, M.; Qin, K.; Shi, W.; Yashinov, A.; Yang, Y.; Yang, L.; Guan, D.; Zhao, L.; Tang, Y.; Chang, Y.; Zhao, L.; Yang, H.; Zhou, H.; Huang, R.; Huang, W. (2020) “Selective N-glycan editing on living cell surfaces for glyco-decryption of functions.” Nat. Chem. Biol. doi.org/10.1038/s41589-020-0551-8.

2.Liu, Y.; Wang, Y.; Dai, W.; Huang, W.; Li, Y.*, Liu, H.* (2020) “Palladium-catalysed C(sp3)-H glycosylation for synthesis of C-alkyl glycoamino acids.” Angew. Chem. Int. Ed. 59(9), 3491-3494.

3.Faridoon; Shi, W.; Qin, K.; Tang, Y.; Li, M.; Guan, D.; Tian, X.; Jiang, B.; Dong, J.; Tang, F.*; Huang, W.* (2019) “New linker structures applied in glycosite-specific antibody drug conjugates.” Org. Chem. Front. 6, 3144-3149. DOI: 10.1039/C9QO00646J.

4.Guan, D.; Chen, F.; Qiu, Y.; Jiang, B.; Gong, L.; Lan, L.*; Huang, W.* (2019) “Sulfonium, an underestimated moiety for structural modification, alters antibacterial profile of vancomycin against multidrug-resistant bacteria” Angew. Chem. Int. Ed. 58(20), 6678-6682. DOI: 10.1002/anie.

5.Chai, H.; Cheng, X.; Zhou, B.; Zhao, L.; Lin, X.; Huang, D.; Lu, W.; Lv, H.; Tang, F.; Zhang, Q.; Huang, W.*; Li, Y.*; Yang, H.* (2019) “Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel.” J. Med. Chem. 62(3), 1373-1384.

6.Guan, D.; Chen, F.; Xiong, L.; Tang, F.; Faridoon; Qiu, Y.; Zhang, N.; Gong, L.; Li, J.; Lan, L.; Huang, W.* (2018) “Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.” J. Med. Chem. 61(1), 286-304.

7.Tang, F.; Wang, L.X.; Huang, W.* (2017) “Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates.” Nat. Protoc. 12(8), 1702-1721.

8.Peng, H.; Chen, B.; Huang, W.; Tang, Y.; Jiang, Y.; Zhang, W.; Huang, Y.* (2017) “Reprogramming tumor-associated macrophages to reverse EGFRT790M resistance by dual-targeting codelivery of gefitinib/vorinostat.” Nano Lett. 17 (12), 7684-7690.

9.Tang, F.; Yang, Y.; Tang, Y.; Tang, S.; Yang, L.; Sun, B.; Jiang, B.; Dong, J.; Liu, H.; Huang, M.; Geng, M.-Y.; Huang, W.* (2016) “One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates.” Org. Biomol. Chem. 14, 9501-9518.

10.Sun, B.; Bao, W.; Tian, X.; Li, M.; Liu, H.; Dong, J.; Huang, W.*. (2014) “A simplified procedure for gram-scale production of sialylglycopeptide (SGP) from egg yolks and subsequent semi-synthesis of Man3GlcNAc oxazoline.” Carbohydr. Res. 396, 62-69.

11.Huang, W.; Giddens, J.; Fan, S.-Q.; Toonstra, C.; and Wang, L.-X. (2012) “Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions.” J. Am. Chem. Soc. 134, 12308-12318.

12.Amin, M.; Huang, W.; Rahman, M.; Wang, L.-X. (2011) Convergent synthesis of homogeneous Glc1Man9GlcNAc2-protein and derivatives as ligands of molecular chaperones in protein quality control. J. Am. Chem. Soc. 133(36), 14404-14417.

13.Schwarz, F., Huang, W., Li, C., Schulz, B.L., Lizak, C., Palumbo, A., Numao, S., Neri, D., Aebi, M., and Wang, L.X. (2010). A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation. Nature Chem. Biol., 6(4), 264-266.

14.Huang, W., Li, C., Li, B., Umekawa, M., Yamamoto, K., Zhang, X., and Wang, L.X. (2009). Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans. J. Am. Chem. Soc., 131(6), 2214-2223.

15.Huang, W., Wang, D.N., Yamada, M, and Wang, L.X. (2009). Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters. J. Am. Chem. Soc., 131(49), 17963-17971.

16.Huang, W., Zhang, H., Dayrazou, F., Kutateladze, T.G., Shi, X., Gozani, O., and Prestwich, G.D. (2007). Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology and molecular modeling. J. Am. Chem. Soc., 129(20), 6498-6506.

jyjl:2012.10.01 - 至今研究员，中国科学院上海药物研究所