xm:张翱
xb:男
zc:研究员
xl:博士
dh:-3426
cz:
dzyj:aozhang@simm.ac.cn
grzy:
zjlb:
zw:研究组长，博士生导师
txdz:上海市浦东新区张江高科技园区祖冲之路555号
grjj:张翱，博士、中国科学院上海药物所研究员、博士生导师、国家****基金获得者和上海“浦江人才计划”优秀奖获得者；曾先后在Georgetown University Medical Center和Harvard Medical School- McLean Hospital进行博士后研究，并于2004年正式成为Harvard Medical School的Professional Investigator， 2004年开始担任Harvard Medical School的Instructor及药物化学研究室助理主任（Assistant Director）。主要从事化学生物学及药物化学研究，尤其是针对神经精神性与肿瘤两大疑难疾病，瞄准在药物研究中具有重要意义和挑战性的G-蛋白偶联受体（GPCR）和受体酪氨酸激酶（RTK）为靶点，系统地开展了基于类药性优势骨架的高效合成、结构优化和聚焦化合物库的构建研究，获得了百余个活性化合物，其中：针对现有中枢镇痛药物的高成瘾性缺点设计的κ-受体激动剂ATPM-ET，已作为新型低成瘾性镇痛药物进入系统临床前研究；针对选择性多巴胺受体激动剂抗帕金森药物易产生异动症的缺点，率先在国际上开展了同时具有D2和5-HT1A受体双重作用机制药物研究，获得的双重全部激动剂化合物MCL-135，作为低毒有效的新型抗帕金森候选药物，正在进行早期临床前研究；在国际上首次完成天然产物Marmycin A的基本骨架的合成，并通过嵌入激酶抑制剂优势药效团构建了咔唑类优势骨架化合物库，获得了一系列靶向酪氨酸激酶c-Met 特异性抑制剂，同时还获得PARP1高活性抑制剂，体内体外均具有较强的抗肿瘤活性，目前已进入临床前系统性药效和安全性评价，极具开发前景。已发表SCI论文90余篇，其中在药物化学国际一级期刊Journal of Medicinal Chemistry 发表论文12篇，以第一申请人申请国内国际专利35项。先后获邀为Chem Rev、Med Res Rev、J Med Chem等就药物发现新策略新理念和相关药物研发进展撰写评述和展望，并担任许多国际期刊的审稿人。曾获2004年Harvard Medical School年度最高学术奖Alfred Pope Award及Adam Cornneel青年奖并获得该基金资助。主持的中科院和上海市“浦江人才计划”结题均获优秀， 2011年获国家****基金。主持完成“十一五”国家重大新药创制重大专项课题、国家自然基金等课题；正在主持 “十二五”国家重大新药创制重大专项课题、国家“****”课题等重要项目。

yjfx:1.作用于酪氨酸激酶或GPCR的分子靶向药物的设计、合成及优化，注重成药性
2.基于天然产物全合成和新合成方法的新结构、新机制小分子药物的发现研究
dblz:(2009.1.1- )
1. Zilan Song, Yanhong Yang, Zhiqing Liu, Xia Peng, Junfeng Guo, Xinying Yang, Kui Wu, Jing Ai, Jian Ding, Meiyu Geng, and Ao Zhang：Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases. J. Med. Chem. ASAP, 2014.

2.Meining Wang, Chi Zhang, Li-Ping Sun, Chunyong Ding, and Ao Zhang: Naphthoquinone-Directed C-H Annulation and Csp3-H Bond Cleavage: One-Pot Synthesis of Tetracyclic Naphthoxazoles. J. Org. Chem., 2014, 79, 4553–4560.

3.Zhiqing Liu, Jing Ai, Xia Peng, Zilan Song, Kui Wu, Jing Zhang, Qizheng Yao, Yi Chen, Yinchun Ji, Yanhong Yang, Meiyu Geng, and Ao Zhang：Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities. ACS Med. Chem. Lett. 2014, 5, 304–308.

4.Li Xing, Zhoulong Fan, Chengyu Hou, Guoping Yong, and Ao Zhang: Synthesis of Pyrazolo[1,2-a]cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach. Adv. Syn. Catal. 2014, 356, 972–976.

5.Zhoulong Fan, Kui Wu, Li Xing, Qizheng Yao, and Ao Zhang: Palladium -Catalyzed Double C-H Activation: One-Pot Synthesis of Benzo[c]pyrazolo[1,2-a]cinnolines from 5-Pyrazolones and Aryl Iodides. Chem. Commun. 2014, 50, 1682 – 1684.

6.Kui Wu, Zhoulong Fan, Yu Xue, Qizheng Yao, and Ao Zhang: Rh(III)-Catalyzed Intermolecular C–H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines. Org. Lett. 2014, 16, 42–45.

7.Xiaolong Jiang, Zilan Song, Chang Xu, Qizheng Yao and Ao Zhang: (D,L)-10-Camphorsulfonic-Acid-Catalysed Synthesis of Diaryl-Fused 2,8-Dioxabicyclo[3.3.1]nonanes from 2-Hydroxychalcones and Naphthol Derivatives. Eur. J. Org. Chem. 2014, 2, 418-425.

8.Pingyuan Wang, Shanshan Song, Zehong Miao, Guangfu Yang, and Ao Zhang: InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/- alkylpyrroles from 1,2-Cyclopropa-3-pyranone and Amines. Org. Lett. 2013, 15, 3852–3855.

9.Dongyu Wang, Shanshan Song, Ye Tian, Youjun Xu, Zehong Miao, and Ao Zhang: Total Synthesis of the Marine Cyclic Depsipeptide Viequeamide A. J. Nat. Prod. 2013, 76, 974–978.

10.Na Ye, John L Neumeyer, Ross J Baldessarini, Xuech Zhen, and Ao Zhang: Recent Progress in the Development of Dopamine Receptor Subtype Compounds: Potential Therapeutic Agents for Neurological and Neuropsychiatric Disorders. Chem. Rev. 2013, 113 (5), PR123–PR178.

11.Na Ye, Chuan-Huizi Chen, Tian Tian Chen, Zilan Song, Jin-Xue He, Xia-Juan Huan, Shanshan Song, Qiufeng Liu, Yi Chen, Jian Ding, Yechun Xu, Ze-Hong Miao, and Ao Zhang: Design, Synthesis and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors. J Med Chem. 2013, 56, 2885–2903.

12.Xuefeng Zhang, Xiaolong Jiang, Chunyong Ding, Qizheng Yao, Ao Zhang: Unexpected N-Glycosidation Reaction of Glycals with 1-Amino-anthracene: Structure Revision and Application to the Synthesis of New Analogues of Marmycin A. Org. Biomol. Chem. 2013, 11, 1383-1389.

13.Chunyong Ding, Shanghui Tu, Fuying Li, Yuanxiang Wang, Qizheng Yao, Wenxiang Hu, Hua Xie, Linghua Meng, Ao Zhang: Correction to Synthesis Study on Marmycin A: Preparation of the C3’-Desmethyl Analogues. J. Org. Chem. 2012, 77, 8374.

14.Wang D, Jia X, Zhang A: Total synthesis of the proposed structure of cyclic hexadepsipeptide veraguamide A. Org. Biomol .Chem. 2012, 10, 7027 – 7030.

15.Chengtang Du, Fulong Li, Xuefeng Zhang, Wenxiang Hu, Qizheng Yao, Ao Zhang: Lewis Acid-Catalyzed Cyclization of Glycals/2-deoxy-D-ribose with Aryl Amines: Additional Findings on Product Structure and Reaction Diastereoselectivity. J. Org. Chem. 2011, 76, 8833-8839.

16.Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang: Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors. Org. Biomol. Chem. 2011, 9, 5930-5933.

17.Hai Zhang, Na Ye, Shanglin Zhou, Lin Guo, Longtai Zheng, Zhili Liu, Bo Gao, Xuechu Zhen, and Ao Zhang: Identification of N-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson\'s Agent Possessing a Dopamine D2 and Serotonin 5-HT1A Dual-Agonist Profile. J. Med. Chem. 2011, 54, 4324-4338.

18.Fulong Li, Chunyong Ding, Meining Wang, Qizheng Yao, Ao Zhang: InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones. J. Org. Chem. 2011, 76, 2820–2827.

19.Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng, Ao Zhang: Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri- substituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)- 5-(3-nitrobenzylamino)- 7- (trifluoromethyl)quinoline as a novel anticancer agent. J. Med. Chem. 2011, 54, 2127–2142.

20.Chunyong Ding, Shanghui Tu, Qizheng Yao, Fulong Li, Yuanxiang Wang, Wenxiang Hu, Ao Zhang: One-Pot Three-step Synthesis of Naphtho [2,3-a]carbazole-5,13-diones Using Tandem Radical Alkylation-Cyclization -Aromatization Reaction Sequence. Adv. Syn. Catal. 2010, 352, 847-853.

21.Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang: Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem. 2010, 53, 1319-1328.

22.Yi Zhang, Zhaobin Han, Fuying Li, Kuiling Ding and Ao Zhang: Highly enantioselective hydrogenation of a-aryl-b-substituted acrylic acids catalyzed by Ir-SpinPHOX. Chem. Commun. 2010, 46, 156–158.

23.Jing Zhang, Ao Zhang: Unprecedented FeCl3?6H2O-Promoted Skeleton-Rearrangement of 1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a New Strategy for the Synthesis of C-1 Quaternary Tetrahydroisoquinolines. Chem. Eur. J. 2009, 15, 11119-11122.

24.Chunyong Ding, Shanghui Tu, Fuying Li, Yuanxiang Wang, Qizheng Yao, Wenxiang Hu, Hua Xie, Linghua Meng, Ao Zhang: Synthesis Study on Marmycin A: Preparation of the C3’-Desmethyl Analogues. J. Org. Chem. 2009, 74, 6111-6119.

25.Jing Zhang, Bing Xiong, Xuechu Zhen, Ao Zhang: Dopamine D1 receptor ligands: Where are we now and where are we going, Med. Res. Rev. 2009, 29, 272-294.

jyjl:1988/09 – 1992/07四川西华师范大学，化学系，本科