xm:胡有洪
xb:男
zc:研究员
xl:博士
dh:**-3526
cz:**
dzyj:yhhu@simm.ac.cn
grzy:
zjlb:研究员；****；新药；
zw:中国科学院上海药物所研究员、博士生导师、课题组长
txdz:上海市浦东新区祖冲之路555号
grjj:1991年毕业于兰州大学化学系，1994年获兰州大学理学硕士学位，1997年获中国科学院上海药物所理学博士学位。1997年9月至1998年8月在日本名古屋大学生命农学院 Minoru Isobe 研究组做访问****；1998年9月至2000年8月在美国乔治城大学医学中心做博士后；2000年9月至2001年3月在美国哈佛大学医学院化学生物学研究所做博士后；2001年在美国 Vivoquest 公司担任药物化学资深研究员。2005年回国任中国科学院上海药物研究所研究员、博士研究生导师。2006年获上海市“浦江人才计划”资助。
yjfx:1.类天然产物和类药性骨架合成新方法的研究与高质量多样性小分子库的构建；
2.新型活性化合物的发现与成药性优化至先导或候选药物的开发；
3.小分子探针的设计合成及相关化学生物学方法探索生物机制研究；
dblz:1.Zhicheng Xie#; Bing Wu #; Yingqiang Liu#; Wenming Ren; Linjiang Tong; Caigui Xiang; Aihuan Wei; Yuanzhuo Gao; Limin Zeng; Hua Xie*; Wei Tang*; Youhong Hu*; Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders, J. Med. Chem., 2020, 63 (3): 1397-1414.

2.Yu Lei#,Wenming Ren#, Cheng-Kun Wang, Rong-Rong Tao, Huai-Jiang Xiang, Li-Li Feng, Yin-Ping Gao, Quan Jiang, Xin Li*, Youhong Hu*, Feng Han*, Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe, Theranostics 2019, Vol. 9, Issue 19, 5672-5680.

3.Yu-Fang Zhang, Wen-Di Duan, Jingjing Chen, and Youhong Hu*, Base-Promoted Cascade Reactions of 3?(1-Alkynyl)chromones with Pyridinium Ylides to Chromeno[2,3-d]azepine Derivatives, J. Org. Chem., 2019, 84, 4467-4472.

4.Wenming Ren, Jingjing Zhang, Cheng Peng, Huaijiang Xiang, Jingjing Chen, Chengyuan Peng, Weiliang Zhu, Ruimin Huang,* Haiyan Zhang,* and Youhong Hu*, Fluorescent Imaging of β?Amyloid Using BODIPY Based Near-Infrared Off?On Fluorescent Probe, Bioconjugate Chem. 2018, 29, 3459-3466.

5.Xueli Yu, Gang Cheng, Lei Zhang, Yu Zhang, Qing Wang, Mengxue Zhao, Limin Zeng, Youhong Hu*, Linyin Feng*, N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination, Scientific Reports, 2018, 8,14040.

6.Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Quan Zhao, Cen Wang, Ping An, Shouqing Luo, Youhong Hu, Xin Xie* and Boxun Lu*, Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes, Brain, 2018: Page 1 of 17.

7.Dong Lu#, Jianan Liu#, Yunzhe Zhang#, Feifei Liu, Limin Zeng, Runze Peng, Li Yang, Huazhou Ying, Wei Tang, Wuhong Chen, Jianping Zuo, Xiankun Tong*, Tao Liu*, Youhong Hu*, Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors, European Journal of Medicinal Chemistry, 2018, Vol145, 328-337.

8.Dong Lu#, Juan Yan#, Lang Wang, Hongchun Liu, Limin Zeng, Minmin Zhang, Wenwen Duan, Yinchun Ji, Jingchen Cao, Meiyu Geng, Aijun Shen*, and Youhong Hu*, Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives, ACS Med. Chem. Lett., 2017, 8 (8), 830–834.

9.Shan Li, Penghui Wan, Jing Ai, Rong Sheng*, Yongzhou Hu*, and Youhong Hu*, Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation, Adv. Synth. Catal., 2017, 359, 772 –778.

10.Dong Lu#, Feifei Liu#, Weiqiang Xing, Xiankun Tong, Lang Wang, Yajuan Wang, Limin Zeng, Chunlan Feng, Li Yang*, Jianping Zuo*, and Youhong Hu*, Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation, ACS Infect. Dis., 2017, 3 (3), 199–205.

11.Yang Liu#, Xia Peng#, Xiaocong Guan#, Dong Lu, Yong Xi, Shiyu Jin, Hui Chen, Limin Zeng, Jing Ai*, Meiyu Geng*, Youhong Hu*, Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors, Eur. J. Med. Chem., 2017, Vol. 126, 122-132.

12.Dong Lu#, Aijun Shen#, Yang Liu, Xia Peng, Weiqiang Xing, Jing Ai, Meiyu Geng*, Youhong Hu*, Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors, Eur. J. Med. Chem., 2016, Vol. 115, 191-200.

13.Yang Liu#, Shiyu Jin#, Xia Peng#, Dong Lu, Limin Zeng, Yiming Sun, Jing Ai*, Meiyu Geng*, Youhong Hu*, Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, Eur. J. Med. Chem., 2016, Vol. 108, 322-333.

14.Ren Wenming#, Xu Mingming#, Liang Steven H., Xiang Huaijiang, Tang Li, Zhang Minkui, Ding Dejun, Li Xin, Zhang Haiyan*, Hu Youhong*, Discovery of a novel fluorescent probe for the sensitive detection of beta-amyloid deposits, Biosensors & Bioelectronics, 2016, 75, 136-141.

15.Xin Li#, Rong-Rong Tao#, Ling-Juan Hong, Juan Cheng, Quan Jiang, Ying-Mei Lu, Mei-Hua Liao, Wei-Feng Ye, Nan-Nan Lu, Feng Han*, Yong-Zhou Hu*, and You-Hong Hu*,Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury, J. Am. Chem. Soc. 2015, 137(38), 12296?12303.

16.Ya-Juan Wang, Dong Lu, Yi-Bin Xu, Wei-Qiang Xing, Xian-Kun Tong, Gui-Feng Wang, Chun-Lan Feng, Pei-Lan He, Li Yang*,Wei Tang*, You-Hong Hu*, Jian-Ping Zuo, A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation, Antimicrobial Agents and Chemotheraphy, 2015, 59(11):7061-72.

17.Weiqiang Xing#, Jing Ai#, Shiyu Jin#, Zhangxing Shi, Xia Peng, Lang Wang,Yinchun Ji, Dong Lu, Yang Liu, Meiyu Geng, Youhong Hu*, Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis, Eur. J. Med. Chem., 2015, 95, 302-312.

18.Yang Liu, Shiyu Jin, Liping Huang, and Youhong Hu*, Phase Transfer Reagent Promoted Tandem Ring-Opening and Ring-Closing Reactions of Unique 3-(1-Alkynyl) Chromones, Org. Lett., 2015, 17 (9), 2134–2137.

19.Shudong Duan#, Suling Huang#, Jian Gong, Yu Shen, Limin Zeng, Ying Feng, Wenming Ren, Ying Leng* and Youhong Hu*, Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders, ACS Med. Chem. Lett., 2015, 6 (4), 386-391.

20.Yang Liu, Shiyu Jin, Zi Wang, Linhua Song, and Youhong Hu*, Microwave Assisted Tandem Heck–Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines, Org. Lett., 2014, 16 (13), 3524–3527.

21.Jia Sheng, Bo Chao, Hong Chen, and Youhong Hu*, Synthesis of Chromeno[2,3-d]imidazol-9(1H)-ones via Tandem Reactions of 3-Iodochromones with Amidines Involving Copper-Catalyzed C–H Functionalization and C–O Bond Formation, Org. Lett., 2013, 15 (17), 4508–4511.

22.Weiqiang Xing#, Yan Fu#, Zhangxing Shi, Dong Lu, Haiyan Zhang*, Youhong Hu,* Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors, Eur. J. Med. Chem., 2013, 63, 95-103.

23.Ming Cheng, Jianwei Yan, Feng Hu, Hong Chen and Youhong Hu*，Palladium-catalyzed cascade reactions of 3-iodochromones with aryl iodides and norbornadiene leading to annulated xanthones，Chemical Science, 2013, 4 (1), 526 – 530.

24.Liping Huang, Yang Liu, Fuchun Xie, Youhong Hu*, An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2-Alkyl Substituted Chromones with Multireactive Sites, Org. Lett., 2012, 14(24), 6122-6125.

25.Jianwei Yan, Ming Cheng, Feng Hu, and Youhong Hu*, Direct Synthesis of Functional Azaxanthones by Using a Domino Three-Component Reaction, Org. Lett., 2012, 14 (12), 3206–3209.

26.Bo Chao, Shijun Lin, Qingdong Ma, Dong Lu, and Youhong Hu*, Copper(I)-Mediated Cascade Reactions: An Efficient Approach to the Synthesis of Functionalized Benzofuro[3,2-d]pyrimidines, Org. Lett., 2012, 14 (9), 2398–2401.

27.Bo Chao, Xian-Kun Tong, Wei Tang, De-Wen Li, Pei-Lan He, Jean-Michel Garcia, Li-Min Zeng, An-Hui Gao, Li Yang, Jia Li, Fa-Jun Nan, Michael Jacobs, Ralf Altmeyer, Jian-Ping Zuo*, and You-Hong Hu*, Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors, J. Med.Chem., 2012, 55(7), 3135-3143.

28.Fuchun Xie#, Hongbing Zhao#, Dewen Li, Hong Chen, Haitian Quan, Xiaojing Shi, Liguang Lou*, and Youhong Hu*, Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors, J. Med. Chem. 2011, 54(9), 3200-3205.

29.Lizhi Zhao, Fuchun Xie, Gang Cheng, Youhong Hu*, A Base-Promoted Tandem Reaction of 3-(1-Alkynyl)chromones with 1,3-Dicarbonyl Compounds: An Efficient Approach to Functional Xanthones, Angew. Chem. Int. Ed., 2009, 48(35), 6520–6523.

30.Gang Cheng and Youhong Hu*, One-pot Synthesis of Furocoumarins through Cascade Addition-Cyclization-Oxidation, Chem. Comm., 2007, 31, 3285-3287.

jyjl:
gzjl:
ktxm:承担及参与多项国家自然科学基金项目、科技部新药创制重大专项课题及上海市科委的重大科学研究项目。

ryhj: 2010年 中国药学会—赛诺菲安万特青年生物药物奖