) 山东师范大学心理学院, 济南 250014
收稿日期:2019-12-18出版日期:2020-12-25发布日期:2020-10-26通讯作者:张文新E-mail:zhangwenxin@sdnu.edu.cn基金资助:* 国家自然科学基金项目(31671156);国家自然科学基金项目(31900776);教育部哲学社会科学研究重大课题攻关项目(17JZD058)The influence of maternal negative parenting, peer victimization and FKBP5 gene on adolescent depressive symptoms
TIAN Xiangjuan, CAO Yanmiao, ZHANG Wenxin() School of Psychology, Shandong Normal University, Jinan 250014, China
Received:2019-12-18Online:2020-12-25Published:2020-10-26Contact:ZHANG Wenxin E-mail:zhangwenxin@sdnu.edu.cn摘要/Abstract
摘要： 累积压力假说与匹配-不匹配假说均可解释远端和近端逆境对个体抑郁的影响, 但鲜有研究考察遗传基因在其中的调节作用。采用问卷法和DNA分型技术, 对970名青少年进行间隔3年的追踪调查。分别以母亲消极教养、同伴侵害为远端和近端压力指标, FKBP5基因多位点累加得分为遗传指标, 考察三者对青少年抑郁的交互作用及性别差异。结果发现, 在男青少年中, E × E × G显著。当累加得分较高、同伴侵害水平较高时, 母亲消极教养显著负向预测抑郁, 符合匹配-不匹配假说; 累加得分较低时, E × E不显著, 但倾向于以累积压力假说的方式发挥作用。女青少年中, E × E × G不显著。研究结果提示, 在男青少年中, 累积压力假说与匹配-不匹配假说均可阐明抑郁的发生机制, 分别适用于携带不同FKBP5基因多位点累加得分的个体。
图/表 5
表1样本特征
| 被试特征 | T1 (N = 2114) | T2 (N = 1823) | 差异检验 |
|---|---|---|---|
| 性别(男生) | 1092 (51.7%) | 922 (50.6%) | c2 = 0.46, df = 1, p = 0.50 |
| 年龄(岁) | 12.31 ± 0.47 | 15.31 ± 0.47 | t(3895) = -0.69, p = 0.99 |
| SES | 0 | 0.005 | t(3935) = -0.69, p = 0.85 |
表1样本特征
| 被试特征 | T1 (N = 2114) | T2 (N = 1823) | 差异检验 |
|---|---|---|---|
| 性别(男生) | 1092 (51.7%) | 922 (50.6%) | c2 = 0.46, df = 1, p = 0.50 |
| 年龄(岁) | 12.31 ± 0.47 | 15.31 ± 0.47 | t(3895) = -0.69, p = 0.99 |
| SES | 0 | 0.005 | t(3935) = -0.69, p = 0.85 |
表2各变量间的相关
| 变量 | CGS | T1母亲 消极教养 | T2同伴 侵害 | T1抑郁 | T2抑郁 |
|---|---|---|---|---|---|
| CGS | 1 | 0.002 | 0.002 | 0.04 | 0.03 |
| T1母亲消极 教养 | -0.03 | 1 | 0.11* | 0.24*** | 0.19*** |
| T2同伴侵害 | 0.04 | 0.15** | 1 | 0.24*** | 0.39*** |
| T1抑郁 | -0.01 | 0.12** | 0.34*** | 1 | 0.48*** |
| T2抑郁 | 0.02 | 0.15** | 0.48*** | 0.49*** | 1 |
| M | — | 1.22/1.13 | 0.42/0.25 | 0.19/0.17 | 0.27/0.26 |
| SD | — | 0.44/0.43 | 0.45/0.35 | 0.22/0.19 | 0.26/0.25 |
表2各变量间的相关
| 变量 | CGS | T1母亲 消极教养 | T2同伴 侵害 | T1抑郁 | T2抑郁 |
|---|---|---|---|---|---|
| CGS | 1 | 0.002 | 0.002 | 0.04 | 0.03 |
| T1母亲消极 教养 | -0.03 | 1 | 0.11* | 0.24*** | 0.19*** |
| T2同伴侵害 | 0.04 | 0.15** | 1 | 0.24*** | 0.39*** |
| T1抑郁 | -0.01 | 0.12** | 0.34*** | 1 | 0.48*** |
| T2抑郁 | 0.02 | 0.15** | 0.48*** | 0.49*** | 1 |
| M | — | 1.22/1.13 | 0.42/0.25 | 0.19/0.17 | 0.27/0.26 |
| SD | — | 0.44/0.43 | 0.45/0.35 | 0.22/0.19 | 0.26/0.25 |
表3FKBP5基因多位点累加得分、母亲消极教养与同伴侵害对男青少年抑郁的影响
 |
表3FKBP5基因多位点累加得分、母亲消极教养与同伴侵害对男青少年抑郁的影响
| |
表4FKBP5基因多位点累加得分、母亲消极教养与同伴侵害对女青少年抑郁的影响
 |
表4FKBP5基因多位点累加得分、母亲消极教养与同伴侵害对女青少年抑郁的影响
| |
图1母亲消极教养与同伴侵害对男青少年抑郁的交互作用
图1母亲消极教养与同伴侵害对男青少年抑郁的交互作用参考文献 103
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